Non-homologous end joining (NHEJ) as the primary conserved DNA double-strand break repair process in human cells. NHEJ, more like a multi-component, multifunctional engine, functions mechanistically for its coordinated movements, assembles, and regulation. Like the old car engine malfunctioning without a linchpin and flexible belt, the NHEJ efficiency arises from a flexible conformational control principle. The NHEJ components were matched on the SKODA 100 car engine built in 1973 in Czechoslovakia. See article by Hammel and Tainer, pp. 1735–1756.

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非同源末端连接 (NHEJ) 作为人类细胞中主要的保守 DNA 双链断裂修复过程。NHEJ 更像是一个多组件、多功能的发动机，其机械运作以协调运动、组装和调节。就像旧汽车发动机在没有关键销和柔性皮带的情况下发生故障一样，NHEJ 效率源于灵活的构象控制原理。NHEJ 部件与 1973 年在捷克斯洛伐克制造的 SKODA 100 汽车发动机相匹配。参见 Hammel 和 Tainer 的文章，第 1735-1756 页。