About 20% of patients with myasthenia gravis (MG) may develop myasthenic crisis (MC) requiring ventilation, either invasive (MV) or non-invasive (NIV) and intensive unit care (ICU). NIV failure in patients with MC can occur up to 60% of cases admitted to ICU. Moreover it is not known the outcome of MC receiving NIV. Purpose of this study was to identify predictors of outcome in MC who underwent non-invasive ventilator support outside ICU setting. We enrolled 90 patients, 53 females and 37 males admitted to University Hospital of Modena (Italy) between January 2000 and September 2020. Median age at MC was 65 years. Thirty-four patients (37.8%) required MV. Thymectomy was performed in 45 cases, associated with thymoma in 55%, with hyperplastic thymus in 33%. First-line treatment was plasmaexchange (38.8%) or intravenous immunoglobulins (45.6%). Males exhibited higher risk of MV than females .Patients in MV were treated with plasmaexchange as first-line therapy . Our in-hospital mortality rate was low. Nine patients underwent tracheostomy which was significantly related to male gender. Comorbidities had significant effect on length of ICU .Our study confirms as predictors of prognosis in our patients male gender, older age at onset, infections as trigger, pneumonia.

大约 20% 的重症肌无力 (MG) 患者可能会出现需要通气的肌无力危象 (MC)，无论是侵入性 (MV) 还是非侵入性 (NIV) 和重症监护室 (ICU)。MC 患者的 NIV 失败可发生在 ICU 收治的高达 60% 的病例中。此外，不知道 MC 接受 NIV 的结果。本研究的目的是确定在 ICU 环境外接受无创呼吸机支持的 ​​MC 预后的预测因素。我们在 2000 年 1 月至 2020 年 9 月期间招收了 90 名患者，其中 53 名女性和 37 名男性入住摩德纳大学（意大利）医院。MC 的中位年龄为 65 岁。34 名患者 (37.8%) 需要 MV。45 例行胸腺切除术，55% 伴有胸腺瘤，33% 伴有胸腺增生。一线治疗是血浆置换（38.8%）或静脉注射免疫球蛋白（45.6%）。男性比女性表现出更高的 MV 风险。MV 患者接受血浆置换作为一线治疗。我们的住院死亡率很低。9例患者接受了与男性显着相关的气管切开术。合并症对 ICU 的长度有显着影响。我们的研究证实，男性、发病年龄较大、感染作为触发因素、肺炎是我们患者预后的预测因素。