Background: Predicting food allergy resolution is essential to minimize the number of restricted foods in children. However, there have been no studies on the natural history of peanut allergy (PA) in Korea. Objective: This study aimed to evaluate the natural course and prognostic factors of immediate-type PA in children till the age of 10 years. Methods: We retrospectively collected data of 122 children who developed PA before 60 months of age from 3 tertiary hospitals in Korea. Diagnosis and resolution of PA was defined as an oral food challenge test or a convincing history of symptoms within 2 h after peanut ingestion. The prognostic factors for resolution of PA were identified using the Cox proportional hazard model. Results: The median (interquartile range) age at diagnosis was 2.0 (1.3–3.0) years. Among the 122 children, PA resolved in 18 (14.8%) children. The level of peanut-specific IgE (sIgE) at diagnosis in the persistence group was significantly higher than that in the resolution group (p = 0.026). The probabilities of resolution of PA were 10.3% and 32.8% at the ages of 6 and 10 years, respectively. A peanut-sIgE level ≥1 kU/L at diagnosis was significantly associated with persistent PA (hazard ratio, 5.99; 95% confidence interval, 1.89–18.87). Conclusions: Only 10.3% of our patients had a probability of developing spontaneous resolution of PA by 6 years of age. Peanut-sIgE levels ≥1 kU/L at diagnosis were associated with the persistence of PA.
Int Arch Allergy Immunol

中文翻译：

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儿童立即型花生过敏的自然病程和预后因素

背景：预测食物过敏的解决对于尽量减少儿童限制食物的数量至关重要。然而，在韩国还没有关于花生过敏（PA）的自然史的研究。目的：本研究旨在评估 10 岁以下儿童即刻型 PA 的自然病程和预后因素。方法：我们回顾性收集了来自韩国 3 家三级医院的 122 名 60 个月前发生 PA 的儿童的数据。PA 的诊断和解决被定义为口服食物激发试验或在花生摄入后 2 小时内有令人信服的症状史。使用 Cox 比例风险模型确定 PA 消退的预后因素。结果：诊断时的中位（四分位距）年龄为 2.0 (1.3-3.0) 岁。在 122 名儿童中，有 18 名 (14.8%) 儿童解决了 PA。持久组诊断时花生特异性IgE（sIgE）水平显着高于消退组（p = 0.026）。PA 在 6 岁和 10 岁时消退的概率分别为 10.3% 和 32.8%。诊断时花生 sIgE 水平≥1 kU/L 与持续性 PA 显着相关（风险比，5.99；95% 置信区间，1.89–18.87）。结论：只有 10.3% 的患者有可能在 6 岁时出现 PA 自然消退。诊断时花生-sIgE 水平≥1 kU/L 与 PA 的持续存在相关。
Int Arch 过敏免疫