A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity,Chemistry & Biodiversity

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A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-08-20 , DOI: 10.1002/cbdv.202100401
Nhat Nam Hoang ₁ , Takeshi Kodama ₁ , Nwet Nwet Win ₁ , Prema _{1,

2} , Kiep Minh Do ₁ , Ikuro Abe _{3,

4} , Hiroyuki Morita ₁

Affiliation

A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2–5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1–5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.

中文翻译：

高良姜根茎新单萜及其抗Vpr活性

新薄荷烷型单萜，alpigalanol（1）中，用四个已知萜烯（共2 - 5）从的70％乙醇提取物的乙酸乙酯可溶级分中分离高良姜根茎。1的结构通过光谱分析确定，包括1D-和2D-NMR。所述提取物A.良姜根茎和所有分离的化合物（1 - 5）具有Vpr基因针对TREX-的HeLa-Vpr基因细胞的抑制活性为1.25μM的浓度没有显示任何细胞毒性。

更新日期：2021-10-19

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