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MR Features Based on LI-RADS Ver. 2018 Correlated with Cytokeratin 19 Expression in Combined Hepatocellular Carcinoma-Cholangiocarcinoma
Journal of Hepatocellular Carcinoma ( IF 4.2 ) Pub Date : 2021-08-21 , DOI: 10.2147/jhc.s325686 Changwu Zhou 1, 2 , Xiaoyan Ni 2 , Xin Lu 2 , Yi Wang 2 , Xianling Qian 2 , Chun Yang 2 , Mengsu Zeng 1, 2
Journal of Hepatocellular Carcinoma ( IF 4.2 ) Pub Date : 2021-08-21 , DOI: 10.2147/jhc.s325686 Changwu Zhou 1, 2 , Xiaoyan Ni 2 , Xin Lu 2 , Yi Wang 2 , Xianling Qian 2 , Chun Yang 2 , Mengsu Zeng 1, 2
Affiliation
Purpose: To investigate the significance of MR features based on the Liver Imaging Reporting and Data System (LI-RADS ver. 2018) for identifying the expression of cytokeratin 19 (CK-19) in patients with combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) before surgery.
Patients and Methods: The study enrolled 174 patients pathologically confirmed to have cHCC-CCA according to the 2019 WHO classification. The preoperative MR imaging features and clinicopathological findings were retrospectively evaluated and compared between the CK-19-positive and CK-19-negative cHCC-CCA groups.
Results: One hundred seventy-four patients (mean age, males vs females: 56.6 ± 10.0 years vs 54.7 ± 14.2 years) were evaluated. The presence of mosaic architecture, targetoid appearance, cholangiectasis, hepatic capsule retraction, and corona enhancement was significantly higher in the CK-19-positive group (all p < 0.05), while nonrim arterial phase hyperenhancement (APHE) was more common in the CK-19-negative group (p = 0.04). The univariate analysis showed that hepatitis B virus infection, CEA > 5 ng/mL, tumor size, nonrim APHE, mosaic architecture, targetoid appearance, cholangiectasis, hepatic capsule retraction, and corona enhancement were significant risk factors for CK-19-positive cHCC-CCA (all p < 0.05). Unfortunately, the multivariate analysis revealed that only corona enhancement (OR = 2.359, p = 0.03) was an independent risk factor associated with CK-19-positive cHCC-CCA.
Conclusion: Corona enhancement is significantly correlated with CK-19 positivity in patients with cHCC-CCA.
Keywords: liver neoplasms, magnetic resonance imaging, cytokeratin 19
中文翻译：
基于 LI-RADS Ver. 的 MR 功能 2018 与细胞角蛋白 19 在联合肝细胞癌-胆管癌中的表达相关
目的：探讨基于肝脏影像报告和数据系统（LI-RADS ver. 2018）的 MR 特征在识别肝细胞癌-胆管癌（cHCC-CCA）患者中细胞角蛋白 19（CK-19）表达的意义) 手术前。
患者和方法：该研究招募了 174 名根据 2019 年 WHO 分类经病理证实患有 cHCC-CCA 的患者。回顾性评估和比较 CK-19 阳性和 CK-19 阴性 cHCC-CCA 组的术前 MR 成像特征和临床病理结果。
结果：评估了 174 名患者（平均年龄，男性与女性：56.6 ± 10.0 岁 vs 54.7 ± 14.2 岁）。CK-19 阳性组的马赛克结构、靶样外观、胆管扩张、肝包膜回缩和电晕增强明显更高（均 p < 0.05），而非边缘动脉期高增强（APHE）在 CK 中更常见-19 阴性组 (p = 0.04)。单因素分析显示，乙型肝炎病毒感染、CEA > 5 ng/mL、肿瘤大小、非边缘 APHE、马赛克结构、靶样外观、胆管扩张、肝包膜回缩和电晕增强是 CK-19 阳性 cHCC-的显着危险因素。 CCA（所有 p < 0.05）。不幸的是，多变量分析显示只有电晕增强（OR = 2.359，p = 0.
结论：电晕增强与 cHCC-CCA 患者 CK-19 阳性显着相关。
关键词：肝脏肿瘤，磁共振成像，细胞角蛋白19
更新日期：2021-08-20
Patients and Methods: The study enrolled 174 patients pathologically confirmed to have cHCC-CCA according to the 2019 WHO classification. The preoperative MR imaging features and clinicopathological findings were retrospectively evaluated and compared between the CK-19-positive and CK-19-negative cHCC-CCA groups.
Results: One hundred seventy-four patients (mean age, males vs females: 56.6 ± 10.0 years vs 54.7 ± 14.2 years) were evaluated. The presence of mosaic architecture, targetoid appearance, cholangiectasis, hepatic capsule retraction, and corona enhancement was significantly higher in the CK-19-positive group (all p < 0.05), while nonrim arterial phase hyperenhancement (APHE) was more common in the CK-19-negative group (p = 0.04). The univariate analysis showed that hepatitis B virus infection, CEA > 5 ng/mL, tumor size, nonrim APHE, mosaic architecture, targetoid appearance, cholangiectasis, hepatic capsule retraction, and corona enhancement were significant risk factors for CK-19-positive cHCC-CCA (all p < 0.05). Unfortunately, the multivariate analysis revealed that only corona enhancement (OR = 2.359, p = 0.03) was an independent risk factor associated with CK-19-positive cHCC-CCA.
Conclusion: Corona enhancement is significantly correlated with CK-19 positivity in patients with cHCC-CCA.
Keywords: liver neoplasms, magnetic resonance imaging, cytokeratin 19
中文翻译：
基于 LI-RADS Ver. 的 MR 功能 2018 与细胞角蛋白 19 在联合肝细胞癌-胆管癌中的表达相关
目的：探讨基于肝脏影像报告和数据系统（LI-RADS ver. 2018）的 MR 特征在识别肝细胞癌-胆管癌（cHCC-CCA）患者中细胞角蛋白 19（CK-19）表达的意义) 手术前。
患者和方法：该研究招募了 174 名根据 2019 年 WHO 分类经病理证实患有 cHCC-CCA 的患者。回顾性评估和比较 CK-19 阳性和 CK-19 阴性 cHCC-CCA 组的术前 MR 成像特征和临床病理结果。
结果：评估了 174 名患者（平均年龄，男性与女性：56.6 ± 10.0 岁 vs 54.7 ± 14.2 岁）。CK-19 阳性组的马赛克结构、靶样外观、胆管扩张、肝包膜回缩和电晕增强明显更高（均 p < 0.05），而非边缘动脉期高增强（APHE）在 CK 中更常见-19 阴性组 (p = 0.04)。单因素分析显示，乙型肝炎病毒感染、CEA > 5 ng/mL、肿瘤大小、非边缘 APHE、马赛克结构、靶样外观、胆管扩张、肝包膜回缩和电晕增强是 CK-19 阳性 cHCC-的显着危险因素。 CCA（所有 p < 0.05）。不幸的是，多变量分析显示只有电晕增强（OR = 2.359，p = 0.
结论：电晕增强与 cHCC-CCA 患者 CK-19 阳性显着相关。
关键词：肝脏肿瘤，磁共振成像，细胞角蛋白19
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