Alzheimer’s disease is a neurodegenerative disorder of the elderly described by progressive cognitive debility. Recent studies have displayed the significance of linear and circular long non-coding RNAs (lncRNAs) in the pathobiology of Alzheimer’s disease. These studies have reported the downregulation of MALAT1, while the upregulation of NEAT1, RP11-543N12.1, SOX21-AS1, BDNF-AS, BACE1-AS, ANRIL, XIST, and some other linear lncRNAs in clinical samples are obtained from these patients or animal models of Alzheimer’s disease. A number of circRNAs such as ciRS-7, ciRS-7, circNF1-419, circHDAC9, circ_0000950,and circAβ-a have been shown to partake in the pathogenesis of this disorder. In the present manuscript, we provide a review of the impact of linear and circular lncRNAs in the pathobiology of Alzheimer’s disease and their potential application as markers for this neurodegenerative condition.

阿尔茨海默病是一种由进行性认知衰弱描述的老年人神经退行性疾病。最近的研究表明线性和环状长非编码 RNA (lncRNA) 在阿尔茨海默病的病理生物学中的重要性。这些研究报道了 MALAT1 的下调，而临床样本中 NEAT1、RP11-543N12.1、SOX21-AS1、BDNF-AS、BACE1-AS、ANRIL、XIST 和其他一些线性 lncRNA 的上调来自这些患者或阿尔茨海默病的动物模型。许多 circRNA，如 ciRS-7、ciRS-7、circNF1-419、circHDAC9、circ_0000950 和 circAβ-a 已被证明参与了这种疾病的发病机制。在目前的手稿中，