Bacterial lipoproteins are membrane proteins derived from both gram-negative and gram-positive bacteria. They seem to have diverse functions not only on bacterial growth, but also play an important role in host’s virulence. Bacterial lipoproteins exert their action on host immune cells via TLR2/1 or TLR2/6. Therefore, bacterial lipoproteins also need to be considered while addressing bacterial pathogenicity besides classical bacterial endotoxin like LPS and other microbial associated molecular patterns such as LTA, and peptidoglycans. In this mini-review, we provide an overview of general bacterial lipoprotein biosynthesis and the need to understand the lipoprotein-mediated pathogenicity in diseases like sepsis.

细菌脂蛋白是来源于革兰氏阴性和革兰氏阳性细菌的膜蛋白。它们似乎不仅对细菌生长具有多种功能，而且在宿主的毒力中也发挥着重要作用。细菌脂蛋白通过 TLR2/1 或 TLR2/6 对宿主免疫细胞发挥作用。因此，除了经典的细菌内毒素（如 LPS）和其他微生物相关的分子模式（如 LTA 和肽聚糖）外，在解决细菌致病性问题时，还需要考虑细菌脂蛋白。在这篇小型综述中，我们概述了一般细菌脂蛋白的生物合成以及了解脂蛋白介导的败血症等疾病的致病性的必要性。