Levonorgestrel-intrauterine-devices (LNG-IUD) are one of the most used contraceptive methods worldwide. While several reviews exist on how LNG-IUDs impact physiology and gynaecological functions, this systematic review focuses on stress, mental health, quality of life, sexual functioning, and effects on brain architecture.

While data on stress is scarce, results on mental health are ambiguous. More consistently, LNG-IUD use seems to improve quality of life and sexual functioning. No studies highlighting the consequences of LNG-IUD use on the brain were found.

The reviewed studies are characterized by a substantial variation in approaches, participant groups, and study quality. More high-quality research assessing the effects of LNG-IUD on mental health, including response to stressors and brain function and structure, is needed to identify women vulnerable to adverse effects of LNG-IUD, also in comparison to oral contraceptives, and to empower women to make more informed choices concerning hormonal contraception.

左炔诺孕酮宫内节育器 (LNG-IUD) 是全球最常用的避孕方法之一。虽然有几篇关于 LNG-IUD 如何影响生理和妇科功能的综述，但本系统综述侧重于压力、心理健康、生活质量、性功能和对大脑结构的影响。

虽然关于压力的数据很少，但关于心理健康的结果却是模棱两可的。更一致的是，使用 LNG-IUD 似乎可以改善生活质量和性功能。没有发现强调使用 LNG-IUD 对大脑的影响的研究。

审查的研究的特点是方法、参与者群体和研究质量存在很大差异。需要更多高质量的研究来评估 LNG-IUD 对心理健康的影响，包括对压力源和大脑功能和结构的反应，以识别易受 LNG-IUD 不利影响的女性，与口服避孕药相比，并赋予权力女性在激素避孕方面做出更明智的选择。