Spray-Dried Quercetin-Lactose Powders for Oral Tablets with Improved Dissolution Rates and Modified Material Properties,Journal of Nanomaterials

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Spray-Dried Quercetin-Lactose Powders for Oral Tablets with Improved Dissolution Rates and Modified Material Properties
Journal of Nanomaterials Pub Date : 2021-08-20 , DOI: 10.1155/2021/2365353
Long Li ₁ , Yuanwei Li ₁ , Zhiying Wu ₁ , Jinhui Chen ₂ , Jia Chen ₁

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This study is aimed at using spray drying method to codisperse it with the commonly used drug carrier lactose in different solvents and then pass it through a spray dryer to obtain different samples. The results showed that the dissolution rate and solubility of the samples obtained by dispersion in hot water and 25% ethanol were significantly higher. The water of crystallization peaks of the raw material disappeared at 105-125°C and 130-150°C (DSC). The excipient lactose had a small upward exothermic peak at 177°C and a significant heat absorption peak at 209°C before untreated (XRD). α-Lactose peaks were observed at 12.5°, 19.1°, 19.6°, and 19.9° at 2θ in both samples, and β-lactose peaks were found at 10.5° at 2θ in sample A, but not in sample B (FTIR). The complex sharp peaks of lactose at 1100 cm^-1 and quercetin at 1700-1000 cm^-1 became moderated (SEM). The sample obtained by spray drying has a slit-type mesoporous structure with an average pore size of about 9.3 nm.

更新日期：2021-08-20

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