Objective. The aim of this study was to evaluate the diagnostic and prognostic value of red blood cell distribution width (RDW) in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). Methods. We retrospectively reviewed 213 CTD-ILD patients and 97 CTD patients without ILD from February 2017 to February 2020. Hospital and office records were used as data sources. CTD-ILD patients were followed up. Results. Patients with CTD-ILD had significantly higher RDW than those with CTD without ILD (). The area under the receiver operating characteristic curve (AUROC) of RDW for discriminating CTD-ILD from CTD without ILD was 0.64 (95% CI: 0.57-0.70, ). The cutoff value of RDW for discriminating CTD-ILD from CTD without ILD was 13.95% with their corresponding specificity (55.9%) and sensitivity (70.1%). Correlation analyses showed that the increased RDW was significantly correlated with decreased DLCO%predicted (, ). Cox multiple regression analysis indicated that RDW (, ) was an independent factor in the survival of CTD-ILD. The best cutoff value of RDW to predict the survival of patients with CTD-ILD was 14.05% (, 95% CI: 0.72-0.84, ). The log-rank test showed a significant difference in survival between the two groups ( and ). Conclusion. RDW was higher in CTD-ILD patients and had a negative correlation with DLCO%predicted. RDW may be an important serum biomarker for severity and prognosis of patients with CTD-ILD.

中文翻译：

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红细胞分布宽度水平与结缔组织病相关间质性肺病 (CTD-ILD) 的关联

客观。本研究的目的是评估红细胞分布宽度 (RDW) 在结缔组织病相关间质性肺病 (CTD-ILD) 患者中的诊断和预后价值。方法。我们回顾性分析了 2017 年 2 月至 2020 年 2 月期间的 213 名 CTD-ILD 患者和 97 名无 ILD 的 CTD 患者。医院和办公室记录用作数据来源。对CTD-ILD患者进行随访。结果。CTD-ILD 患者的 RDW 显着高于无 ILD 的 CTD 患者（）。RDW 区分 CTD-ILD 与 CTD 无 ILD 的受试者工作特征曲线下面积 (AUROC) 为 0.64 (95% CI: 0.57-0.70,）。RDW 区分 CTD-ILD 与 CTD 无 ILD 的临界值为 13.95%，其相​​应的特异性 (55.9%) 和敏感性 (70.1%)。相关性分析表明，RDW 增加与 DLCO% 预测值降低显着相关（, ）。Cox 多元回归分析表明，RDW (, )是 CTD-ILD 生存的独立因素。RDW预测CTD-ILD患者生存的最佳截断值为14.05%（, 95% CI: 0.72-0.84,）。对数秩检验显示两组的生存率存在显着差异（ 和 ）。 结论。CTD-ILD 患者的 RDW 较高，与预测的 DLCO% 呈负相关。RDW可能是CTD-ILD患者严重程度和预后的重要血清生物标志物。