Background Neonates born somewhere else (outborn) and treated in a referral centre have different microbiological profile. We report the microorganism’s profile and antimicrobial resistance (AMR) in blood culture proven sepsis in outborn neonates. Methods Culture positive neonatal sepsis from a neonatal unit of a referral institute catering to outborn neonates was studied over an 18 months duration. Data from the hospital information system were used to analyse the culture positivity rates, the spectrum of the microorganisms isolated and AMR pattern. Results Out of 5258 admitted neonates, 3687 blood samples were sent for suspect sepsis. The blood cultures were positive in 537 (14.6%) samples from 514 neonates. Gram-positive cocci (GPC) were the most common [240 (45%)] followed by gram-negative bacilli (GNB) [233 (43.4%)] and fungi [64 (11.9%)]. Coagulase negative staphylococcus (CONS) contributed to two-thirds of GPC followed by Klebsiella [93 (17.3%)] and Acinetobacter species [52 (9.7%)]. In 403 (75%) neonates, organisms grew in the samples sent at or within 24 h of admission. The case fatality rate was significantly higher in those with culture positive sepsis. The resistance to meropenem and imipenem was documented in 57.1% and 49.7%, respectively and 48% of the GNB was multidrug resistant. Conclusions CONS followed by Klebsiella species were the most common organisms isolated. Three-fourths of the neonates had organisms grown at or within 24 h from admission. More than half of the GNB were multidrug resistant. The case fatality rate was significantly higher in those with culture positive sepsis.

中文翻译：

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印度北部新生儿的微生物概况和抗菌素耐药性模式：一项基于医院的观察性研究

背景 在其他地方（出生）出生并在转诊中心接受治疗的新生儿具有不同的微生物特征。我们报告了血培养证实的新生儿败血症中微生物的特征和抗菌素耐药性 (AMR)。方法 在 18 个月的时间里，研究了来自转诊机构的新生儿单元的培养阳性新生儿败血症，该转诊机构为新生儿提供服务。医院信息系统数据用于分析培养阳性率、分离微生物谱和AMR谱。结果 在 5258 名入院新生儿中，有 3687 份血液样本被送去疑似败血症。来自 514 名新生儿的 537 份 (14.6%) 样本的血培养结果呈阳性。革兰氏阳性球菌 (GPC) 是最常见的 [240 (45%)]，其次是革兰氏阴性杆菌 (GNB) [233 (43.4%)] 和真菌 [64 (11.9%)]。凝固酶阴性葡萄球菌 (CONS) 占 GPC 的三分之二，其次是克雷伯氏菌 [93 (17.3%)] 和不动杆菌 [52 (9.7%)]。在 403 名 (75%) 新生儿中，生物体在入院时或入院后 24 小时内发送的样本中生长。培养阳性脓毒症患者的病死率明显较高。对美罗培南和亚胺培南的耐药率分别为 57.1% 和 49.7%，48% 的 GNB 具有多重耐药性。结论 CONS其次是克雷伯菌属是最常见的分离生物。四分之三的新生儿在入院后 24 小时内或 24 小时内生长出有机体。超过一半的 GNB 具有多重耐药性。培养阳性脓毒症患者的病死率明显较高。