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Night shift work and breast cancer risk: a meta-analysis of observational epidemiological studies.
Carcinogenesis ( IF 4.7 ) Pub Date : 2021-10-26 , DOI: 10.1093/carcin/bgab074
Nhung Thi Hong Van 1 , Tung Hoang 1 , Seung-Kwon Myung 1, 2, 3
Affiliation  

Previous observational epidemiological studies have reported inconsistently the association between night shift work (NSW) and the risk of breast cancer (BC). This study aimed to investigate those associations by using a meta-analysis of observational epidemiological studies. We searched PubMed and EMBASE using keywords related to this topic from inception till November 2020. The pooled effect sizes such as odds ratio (OR), hazard ratio (HR) or relative risk (RR) with 95% confidence interval (CI) were calculated using a random-effects model. In the meta-analysis of a total of 32 observational studies including 13 case-control studies, 4 nested case-control studies and 15 cohort studies, NSW significantly increased the risk of BC (OR/RR/HR, 1.11; 95% CI, 1.04-1.20; I2 = 72.4%). In the subgroup meta-analysis by type of study, NSW was also associated with the increased risk of BC in case-control studies (OR, 1.34; 95% CI, 1.17-1.53; I2 = 63.8%). However, no significant association was found in both nested case-control studies (OR, 1.14; 95% CI, 0.89-1.46; I2 = 65.8%) and cohort studies (RR/HR, 0.98; 95% CI, 0.93-1.03; I2 = 25.3%). Besides, there was no significant association between NSW for over 20 years and the risk of BC (OR/RR/HR, 1.03; 95% CI, 0.95-1.11; I2 = 36.6%, n = 14). Given that cohort studies provide higher evidence than case-control studies, there is no association between NSW and the risk of BC.

中文翻译:

夜班工作和乳腺癌风险:观察性流行病学研究的荟萃分析。

以前的观察性流行病学研究不一致地报告了夜班工作 (NSW) 与乳腺癌 (BC) 风险之间的关联。本研究旨在通过使用观察性流行病学研究的荟萃分析来调查这些关联。从开始到 2020 年 11 月,我们使用与该主题相关的关键字搜索了 PubMed 和 EMBASE。计算了汇总效应大小,例如优势比 (OR)、风险比 (HR) 或具有 95% 置信区间 (CI) 的相对风险 (RR)使用随机效应模型。在总共 32 项观察性研究(包括 13 项病例对照研究、4 项巢式病例对照研究和 15 项队列研究)的荟萃分析中,NSW 显着增加了 BC 的风险(OR/RR/HR,1.11;95% CI, 1.04-1.20;I2 = 72.4%)。在按研究类型进行的亚组荟萃分析中,在病例对照研究中,新南威尔士州也与 BC 风险增加有关(OR,1.34;95% CI,1.17-1.53​​;I2 = 63.8%)。然而,在嵌套病例对照研究(OR,1.14;95% CI,0.89-1.46;I2 = 65.8%)和队列研究(RR/HR,0.98;95% CI,0.93-1.03; I2 = 25.3%)。此外,新南威尔士州 20 多年来与 BC 风险之间没有显着关联(OR/RR/HR,1.03;95% CI,0.95-1.11;I2 = 36.6%,n = 14)。鉴于队列研究提供比病例对照研究更高的证据,新南威尔士州与 BC 风险之间没有关联。93-1.03;I2 = 25.3%)。此外,新南威尔士州 20 多年来与 BC 风险之间没有显着关联(OR/RR/HR,1.03;95% CI,0.95-1.11;I2 = 36.6%,n = 14)。鉴于队列研究提供比病例对照研究更高的证据,新南威尔士州与 BC 风险之间没有关联。93-1.03;I2 = 25.3%)。此外,新南威尔士州 20 多年来与 BC 风险之间没有显着关联(OR/RR/HR,1.03;95% CI,0.95-1.11;I2 = 36.6%,n = 14)。鉴于队列研究提供比病例对照研究更高的证据,新南威尔士州与 BC 风险之间没有关联。
更新日期:2021-08-19
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