Understanding the electroencephalography features of young and old patients treated with anesthetic drugs is important to allow accurate drug use in elderly patients. This study aimed to monitor the intracranial electroencephalography (in the cortex and hippocampus) in free-moving young and old mice under midazolam administration. Behavioral assessment revealed that compared with young mice, old mice had a longer immobility time with a similar midazolam dose. In both young and old mice, midazolam significantly suppressed the total, δ (0.5-4 Hz), θ (4-8 Hz), and α (8-12 Hz) power, and thus induced an increase in the relative β (12-30 Hz) and γ (30-140 Hz) power. Age had a main effect on the γ frequency; specifically, under normal conditions, old mice had a lower γ power than young mice. After midazolam administration, the relative power of high γ frequency (50-140 Hz) remained lower in old mice than in young mice. Our findings suggest that a lower γ power is indicative of an aging brain.

中文翻译：

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咪达唑仑给药后年轻和老年小鼠的颅内脑电图特征。

了解接受麻醉药物治疗的年轻和老年患者的脑电图特征对于老年患者的准确用药非常重要。本研究旨在监测咪达唑仑给药下自由活动的年轻和年老小鼠的颅内脑电图（皮层和海马）。行为评估显示，与年轻小鼠相比，在相似的咪达唑仑剂量下，老年小鼠的不动时间更长。在年轻和年老的小鼠中，咪达唑仑显着抑制总功率、δ (0.5-4 Hz)、θ (4-8 Hz) 和 α (8-12 Hz) 功率，从而诱导相对 β (12 -30 Hz) 和 γ (30-140 Hz) 功率。年龄对γ频率有主要影响；具体来说，在正常条件下，老年小鼠的γ功率低于年轻小鼠。给予咪达唑仑后，老年小鼠的高γ频率（50-140 Hz）的相对功率仍然低于年轻小鼠。我们的研究结果表明，较低的 γ 功率表明大脑正在老化。