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Lysosome-targeting chimeras evolve
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2021-08-19 , DOI: 10.1038/s41589-021-00835-1
Joshiawa Paulk 1
Affiliation  

LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC design principles.

中文翻译:

溶酶体靶向嵌合体进化

LYTACs 通过将细胞外蛋白质募集到介导向溶酶体递送的细胞受体来诱导细胞外蛋白质的选择性降解。靶向肝脏特异性 ASGPR 的 GalNAc-LYTAC 和 MoDE-As 的最新发展使细胞类型限制性溶酶体蛋白降解成为可能,并揭示了新的 LYTAC 设计原则。
更新日期:2021-08-19
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