Abstract—

The review summarizes current knowledge on the role of the nociceptin/orphanin (N/OFQ) system in the regulation of brain functions. The nociceptin receptor (NOPr) was originally identified in 1994 (Bunzow et al., 1994; Mollereau et al., 1994). In 1995, an endogenous peptide consisting of 17 residues was found as a high affinity ligand for the NOPr (Reinscheid et al., 1995). N/OFQ has a broad spectrum of activity and can act as an opioid-like as well as an anti-opioid peptide. The high level of N/OFQ and NOPr mRNA expression in the limbic brain regions, suggests that the N/OFQ system is involved in regulation of emotions, reward, pain sensitivity, stress responsiveness, sexual behavior and aggression. It is suggested that N/OFQ may be also involved in regulation of addiction; however, it is still not well understood whether an increased vulnerability to drugs of abuse may be associated with dysregulation of this system. Further research is clearly needed for the development of new drugs aimed at pharmacotherapy of depression, anxiety disorders, alcohol and other types of addiction.

中文翻译：

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Nociceptin 在阿片类药物调节脑功能中的作用

摘要——

该综述总结了目前关于伤害感受素/孤啡肽 (N/OFQ) 系统在调节大脑功能中的作用的知识。伤害感受素受体 (NOPr) 最初于 1994 年被鉴定（Bunzow 等人，1994 年；Mollereau 等人，1994 年）。1995 年，一种由 17 个残基组成的内源性肽被发现作为 NOPr 的高亲和力配体（Reinscheid 等，1995）。N/OFQ 具有广泛的活性，可以作为阿片类药物和抗阿片肽。边缘大脑区域中 N/OFQ 和 NOPr mRNA 的高水平表达表明 N/OFQ 系统参与情绪、奖励、疼痛敏感性、压力反应、性行为和攻击性的调节。建议 N/OFQ 也可能参与成瘾的调节；然而，对滥用药物的脆弱性增加是否可能与该系统的失调有关，目前仍不清楚。显然需要进一步研究开发针对抑郁症、焦虑症、酒精和其他类型成瘾的药物治疗的新药。