Background: A promising approach to solve the problem of cytostatic toxicity is targeted drug transport using magnetic nanoparticles (MNPs).
Purpose: To use calculation to determine the optimal characteristics of the magnetic field for controlling MNPs in the body, and to evaluate the efficiency of magnetically controlled delivery of MNPs in vitro and in vivo to a tumour site in mice.
Material and Methods: For the in vitro study, reference MNPs were used, while for in vivo studies, MNPs coated in polylactide including fluorescent indocyanine (MNPs-ICG) were used. The in vivo luminescence intensity study was performed in mice with tumours, with and without of a magnetic field at the sites of interest. The studies were performed on a hydrodynamic stand developed at the Institute of Experimental Medicine of the Almazov National Medical Research Centre of the Ministry of Health of Russia.
Results: The use of neodymium magnets facilitated selective accumulation of MNPs. One minute after the administration of MNPs-ICG to mice with a tumour, MNPs-ICG predominantly accumulated in the liver, in the absence and presence of a magnetic field, which indicates its metabolic pathway. The intensity of the fluorescence in the animals’ livers did not change over time, although an increase in fluorescence in the tumour was observed in the presence of a magnetic field.
Conclusion: This type of MNP, used in combination with a magnetic field of calculated strength, can form the basis for the development of magnetically controlled transport of cytostatic drugs into tumour tissue.



中文翻译：

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控制用于靶向递送细胞抑制剂的磁性氧化铁纳米颗粒的运动

背景：解决细胞抑制毒性问题的一种有前途的方法是使用磁性纳米粒子（MNPs）进行靶向药物转运。
目的：利用计算确定控制体内 MNPs 的磁场的最佳特性，并评估在体外和体内将 MNPs 磁控递送至小鼠肿瘤部位的效率。
材料与方法：对于体外研究，使用了参考 MNP，而对于体内研究，使用了涂有聚丙交酯的 MNP，包括荧光吲哚菁 (MNPs-ICG)。体内发光强度研究是在患有肿瘤的小鼠中进行的，在感兴趣的部位有或没有磁场。这些研究是在俄罗斯卫生部阿尔马佐夫国家医学研究中心实验医学研究所开发的流体动力学支架上进行的。
结果：钕磁铁的使用促进了 MNP 的选择性积累。在将 MNPs-ICG 施用于肿瘤小鼠一分钟后，MNPs-ICG 主要在肝脏中积累，在磁场的缺失和存在下，这表明其代谢途径。尽管在存在磁场的情况下观察到肿瘤中的荧光增加，但动物肝脏中的荧光强度并未随时间而变化。
结论：这种类型的 MNP 与计算强度的磁场结合使用，可以为开发细胞抑制药物向肿瘤组织的磁控转运奠定基础。