One new benzophenone derivative, named penibenzophenone C (1), and a new benzophenone natural product, neamed penibenzophenone D (2), together with two known compounds (3, 4) were isolated from the EtOAc extract of the endophytic fungus Penicillium sp. isolated from the mangrove Acanthus ilicifolius L. collected in the South China Sea. The structures of 1–4 were elucidated by extensive NMR spectral interpretation and MS data. The new compounds 1 and 2 showed moderate antibacterial activities against methicillin-resistant Staphylococcus aureus with the MIC values of 3.12 and 6.25 μg ml⁻¹, respectively.

从内生真菌Penicillium sp.的EtOAc 提取物中分离出一种新的二苯甲酮衍生物，命名为penibenzophenone C ( 1 ) 和一种新的二苯甲酮天然产物， need penibenzophenone D ( 2 )，以及两种已知的化合物( 3 , 4 ) 。从在南海收集的红树林Acanthus ilicifolius L. 中分离。通过广泛的 NMR 光谱解释和 MS 数据阐明了1-4的结构。新化合物1和2对耐甲氧西林金黄色葡萄球菌表现出中等抗菌活性MIC 值分别为 3.12 和 6.25 μg ml ^-1。