New evidence has emerged that DNA can bind to cell surface HLA class II molecules. If true, this surprising interaction could lead to T cell and B cell activation by DNA, and surface DNA could also provide a target for cell killing by anti-DNA antibodies in systemic lupus erythematosus.

中文翻译：

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DNA-HLA II 类相互作用是 SLE 中缺失的环节吗？

新的证据表明 DNA 可以与细胞表面 HLA II 类分子结合。如果属实，这种令人惊讶的相互作用可能会导致 T 细胞和 B 细胞被 DNA 激活，而表面 DNA 也可以为系统性红斑狼疮中的抗 DNA 抗体提供杀死细胞的靶标。