Cyclin-dependent kinase 7 (CDK7) is implicated in regulating the expression of cancer-dependent genes, and multiple CDK7-targeted therapies are currently under clinical investigation. Three recent studies elucidate the structure of human transcription machinery, offering vital mechanistic insights into CDK7 function and a potential pharmacodynamic marker of CDK7 activity in tumors.

中文翻译：

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Mediator 捕获 CDK7，这是癌症中一个有吸引力的转录靶点

细胞周期蛋白依赖性激酶 7 (CDK7) 参与调节癌症依赖性基因的表达，目前正在临床研究多种 CDK7 靶向疗法。最近的三项研究阐明了人类转录机制的结构，为 CDK7 功能和肿瘤中 CDK7 活性的潜在药效学标志物提供了重要的机制见解。