Background

Guillain-Barré syndrome (GBS) is the main cause of acute and subacute flaccid paralysis in western nations since the eradication of poliomyelitis.

Objective

The aim of this study is to investigate epidemiology and mortality characteristics of GBS in the north of Iran.

Material and methods

In this study, the hospital information system (HIS) was used to access each patient’s information. The final 174 cases were examined in terms of age, sex, place of residence, the year of referral, the month of referral, the season of referral, client city, accompanying background disease, and the type of GBS.

Results

The mean incidence rate in Guilan province was about 0.69 in 100,000 persons, and the case fatality rate was 10.34%. The most reported type of GBS was AIDP (33.90%), and the most common symptom was upper and lower limbs paresis in 65 cases (37%). Respiratory distress (P = < 0.001), complications during hospitalization (P = 0.0001), and ICU requirement (P = 0.001) were significantly higher in dead patients.

Conclusion

In this study, the incidence of GBS was higher in men than women and the highest number of cases was in the age group of 60 to 75 years. The significant point was the high-case fatality rate in Guilan province compared to the previous studies. The complications during hospitalization such as respiratory distress, ICU requirement, and underlying disease had a significant relation with the fatality of GBS.

中文翻译：

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伊朗北部吉兰-巴雷综合征成人和儿童流行病学和死亡率相关因素的十年评估

背景

自从消灭脊髓灰质炎以来，格林-巴利综合征 (GBS) 是西方国家急性和亚急性弛缓性麻痹的主要原因。

目标

本研究的目的是调查伊朗北部 GBS 的流行病学和死亡率特征。

材料和方法

在本研究中，医院信息系统 (HIS) 用于访问每位患者的信息。对最终 174 例病例进行了年龄、性别、居住地、转诊年份、转诊月份、转诊季节、客户城市、伴随背景疾病和 GBS 类型的检查。

结果

桂兰省10万人平均发病率为0.69左右，病死率为10.34%。报道最多的GBS类型为AIDP（33.90%），最常见的症状为上下肢麻痹65例（37%）。 死亡患者的呼吸窘迫 ( P  = < 0.001)、住院期间的并发症 ( P  = 0.0001) 和 ICU 需求 ( P = 0.001) 显着更高。

结论

本研究中，男性GBS发病率高于女性，60～75岁年龄组GBS发病率最高。与之前的研究相比，重要的一点是桂兰省的病死率很高。住院期间呼吸窘迫、ICU需求、基础疾病等并发症与GBS的病死率有显着关系。