Background

Neurological manifestations of COVID-19 infection are well recognized. Seizures and status epilepticus (SE) have been reported as possible manifestations and/or complications of SARS-CoV-2 infection at different disease stages, but few data are known about the type, severity, treatment response, and recurrence.

Methods

Single-center retrospective case series.

Results

This case series describes four COVID-19-positive patients admitted to an Italian University Hospital, who developed status epilepticus during the active phase of disease, independently from the severity of respiratory symptoms. Two of them presented a relapse after resolution of the acute viral infection, a feature that has not been previously reported.

Conclusions

Although a possible association between SE and COVID-19 has been reported, the exact etiopathogenetic mechanism remains still not understood. Our series adds new insights to shed further light on this controversial issue.

中文翻译：

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SARS-CoV-2感染中的新发癫痫持续状态：病例系列

背景

COVID-19 感染的神经系统表现是公认的。据报道，癫痫发作和癫痫持续状态 (SE) 是 SARS-CoV-2 感染在不同疾病阶段的可能表现和/或并发症，但关于类型、严重程度、治疗反应和复发的数据很少。

方法

单中心回顾性病例系列。

结果

本病例系列描述了意大利大学医院收治的四名 COVID-19 阳性患者，他们在疾病活动期出现癫痫持续状态，与呼吸道症状的严重程度无关。其中两人在急性病毒感染消退后出现复发，这是以前从未报道过的特征。

结论

尽管已经报道了 SE 和 COVID-19 之间可能存在的关联，但确切的发病机制仍然不清楚。我们的系列增加了新的见解，以进一步阐明这个有争议的问题。