Purpose of review

As fields such as neurotoxicity evaluation and neuro-related drug research are increasing in popularity, there is a demand for the expansion of neurotoxicity research. Currently, neurotoxicity is assessed by measuring changes in weight and behavior. However, measurement of such changes does not allow the detection of subtle and inconspicuous neurotoxicity. In this review, methods for advancing neurotoxicity research are divided into molecule-, cell-, circuit-, and animal model-based methods, and the results of previous studies assessing neurotoxicity are provided and discussed.

Recent findings

In coming decades, cooperation between universities, national research institutes, industrial research institutes, governments, and the private sector will become necessary when identifying alternative methods for neurotoxicity evaluation, which is a current goal related to improving neurotoxicity assessment and an appropriate approach to neurotoxicity prediction. Many methods for measuring neurotoxicity in the field of neuroscience have recently been reported. This paper classifies the supplementary and complementary experimental measures for evaluating neurotoxicity.

中文翻译：

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评估神经毒性的先进方法分类

审查目的

随着神经毒性评价和神经相关药物研究等领域的日益普及，需要扩大神经毒性研究。目前，通过测量体重和行为的变化来评估神经毒性。然而，对这种变化的测量不允许检测到细微和不显眼的神经毒性。在这篇综述中，推进神经毒性研究的方法分为基于分子、细胞、回路和动物模型的方法，并提供和讨论了先前评估神经毒性的研究结果。

最近的发现

未来几十年，在确定神经毒性评估的替代方法时，大学、国家研究机构、工业研究机构、政府和私营部门之间的合作将变得必要，这是与改进神经毒性评估和神经毒性预测的适当方法相关的当前目标. 最近报道了神经科学领域中测量神经毒性的许多方法。本文对评估神经毒性的补充和补充实验措施进行了分类。