Aseries of 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivatives (Miconazole analogs) was obtained via copper catalyzed azide-alkyne cycloaddition as the key step. The synthesized compounds were evaluated for antimicrobial activity against Candida genus strains as well as filamentous fungi (Mucor hiemalis, Aspergillus fumigatus and Rhizopus oryzae). A 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivative exhibited remarkable selectivity comparable to that of Itraconazole against Rhizopus oryzae.

中文翻译：

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1-(2-苄氧基-2-苯基乙基)-1,2,3-三唑咪康唑类似物的合成和抗真菌活性评价

作为关键步骤，通过铜催化的叠氮化物-炔烃环加成反应获得了一系列 1-(2-芳氧基-2-苯乙基)-1,2,3-三唑衍生物（咪康唑类似物）。评价合成的化合物对念珠菌属菌株以及丝状真菌（Mucor hiemalis、Aspergillus fumigatus和Rhizopus oryzae）的抗菌活性。1-(2-芳氧基-2-苯乙基)-1,2,3-三唑衍生物对米根霉表现出与伊曲康唑相当的选择性。