This review summarizes results of clinical studies of the efficacy and safety of topical dosage forms of non-steroidal anti-inflammatory drugs (NSAIDs). Examples of the delivery of active substances to target tissues after cutaneous application of the drugs are described. Literature data on reduced concentrations of active substances in the blood and reduced side effects of topical dosage forms of NSAIDs as compared with systemic agents are presented and show that local drug administration can reduce the number of side effects.

中文翻译：

---

非甾体抗炎药外用剂型及其药代动力学决定剂的有效性和安全性（综述）

本综述总结了非甾体抗炎药 (NSAIDs) 局部剂型的有效性和安全性的临床研究结果。描述了在皮肤应用药物后将活性物质递送至靶组织的实例。与全身用药相比，NSAIDs 局部剂型降低了血液中活性物质的浓度并减少了副作用的文献数据表明，局部给药可以减少副作用的数量。