Joint diseases are frequently treated using intra-articular injection forms of drugs based on glucocorticosteroids, many of which have disadvantages that hinder increasing their effectiveness. Liposomal forms of glucocorticosteroids are of particular interest for intra-articular administration in the treatment of arthritis. Liposomes with an average vesicle size of 86 ± 5 nm and a dexamethasone concentration of 2.2 ± 0.007 mg/mL were obtained in the present study. The therapeutic efficacy of the obtained liposomes with dexamethasone was studied in comparison with intra-articular administration of dexamethasone solution at the same dose in a rat rheumatoid arthritis model. The criteria for drug effectiveness were macro- and microscopic signs of arthritis in the ankle joints. The liposomal form turned out to be much more effective in comparison to the solution at equal doses as a medicine for reducing the main pathoanatomical signs of the inflammatory process in joints.

关节疾病经常使用基于糖皮质激素的药物的关节内注射形式来治疗，其中许多具有阻碍提高其有效性的缺点。脂质体形式的糖皮质激素特别适用于关节内给药治疗关节炎。在本研究中获得了平均囊泡大小为 86 ± 5 nm 和地塞米松浓度为 2.2 ± 0.007 mg/mL 的脂质体。在大鼠类风湿性关节炎模型中，与相同剂量的地塞米松溶液的关节内给药相比，研究了获得的脂质体与地塞米松的治疗功效。药物有效性的标准是踝关节关节炎的宏观和微观体征。