Depression is a common occurrence in patients with Parkinson's disease (PD); however, its pathophysiology is still unclear. This study assessed the association between the integrity of white matter and depressive symptoms in patients with PD. 67 patients with PD were divided into a non-depressed PD group (ndPD, n = 30) and a depressed PD group (dPD, n = 37). The dPD group was further subdivided into a mild-moderately depressed PD (mdPD, n = 22) and a severely depressed PD group (sdPD, n = 15). Tract-Based Spatial Statistics was used to compare fractional anisotropy (FA) between groups. Region-of-interest analysis was used to explore changes in diffusivity indices in the regions showing FA abnormalities. The sdPD patients exhibited significantly reduced FA in the left superior longitudinal fasciculus, uncinate fasciculus, anterior corona radiata, corticospinal tract, and bilateral inferior fronto-occipital fasciculus when compared with the ndPD patients, but the decreased FA was within a smaller area when compared with the mdPD patients. No significant difference in FA was found between the mdPD and ndPD groups. Among the dPD patients, FA values in the left superior longitudinal fasciculus negatively correlated with BDI scores. Impaired white matter integrity in the prefronto-limbic/temporal circuitry, mainly in the left hemisphere, is associated with severe, but not mild-moderate depressive symptoms in patients with PD.

抑郁症在帕金森病 (PD) 患者中很常见；然而，其病理生理学仍不清楚。本研究评估了 PD 患者白质完整性与抑郁症状之间的关联。将 67 名 PD 患者分为非抑郁 PD 组（ndPD，n = 30）和抑郁 PD 组（dPD，n = 37）。dPD组进一步细分为轻度中度抑郁PD（mdPD，n = 22）和重度抑郁PD组（sdPD，n = 15）。基于区域的空间统计用于比较组间的分数各向异性 (FA)。感兴趣区域分析用于探索显示 FA 异常的区域中扩散指数的变化。sdPD 患者的左上纵​​束、钩束、与ndPD患者相比，前放射冠、皮质脊髓束和双侧额枕下束，但与mdPD患者相比，FA降低的区域较小。mdPD 和 ndPD 组之间的 FA 没有显着差异。在 dPD 患者中，左上纵束的 FA 值与 BDI 评分呈负相关。前额-边缘/颞叶回路中白质完整性受损，主要发生在左半球，与 PD 患者的重度抑郁症状相关，但与轻度中度抑郁症状无关。mdPD 和 ndPD 组之间的 FA 没有显着差异。在 dPD 患者中，左上纵束的 FA 值与 BDI 评分呈负相关。前额-边缘/颞叶回路中白质完整性受损，主要发生在左半球，与 PD 患者的重度抑郁症状相关，但与轻度中度抑郁症状无关。mdPD 和 ndPD 组之间的 FA 没有显着差异。在 dPD 患者中，左上纵束的 FA 值与 BDI 评分呈负相关。前额-边缘/颞叶回路中白质完整性受损，主要发生在左半球，与 PD 患者的重度抑郁症状相关，但与轻度中度抑郁症状无关。