Covid-19 pandemic reveals that the virus causes Covid-19 associated coagulopathy and it is well known that thrombotic risk is associated with ethnicity. To describe the Covid-19 associated coagulopathy in Indian population and to correlate it with the disease severity and survivor status. A cross sectional descriptive study of 391 confirmed Covid-19 cases was carried out over a period of 1.5 months. Patients were categorised as mild to moderate, severe and very severe and also labelled as survivors and non survivors. Prothrombin time (PT), International normalised ratio (INR), activated partial thromboplastin time, D dimer, Fibrin degradation products (FDP), fibrinogen and thrombin time and platelet counts were investigated among the subgroups. Mean age was higher in patients with severe disease (57.62 ± 13.08) and among the non survivors (56.54 ± 12.78). Statistically significant differences in D dimer, FDP, PT, INR and age were seen among the 3 subgroups and survivors. Strong significant positive correlation was noted between D dimer and FDP (r = 0.838, p < .001), PT and INR (r = 0.986, p < 0.001). D dimer was the best single coagulation parameter as per the area under curve (AUC: 0.762, p < 0.001) and D dimer + FDP was the best combination parameter (AUC: 0.764, p = 0) to differentiate mild moderate from severe disease. Raised levels of D dimer, FDP, PT, PT INR and higher age correlated positively with disease severity and mortality in Indian Population.

Covid-19 大流行表明该病毒会导致与 Covid-19 相关的凝血病，众所周知，血栓形成风险与种族有关。描述印度人群中与 Covid-19 相关的凝血病，并将其与疾病严重程度和幸存者状态相关联。在 1.5 个月内对 391 例确诊的 Covid-19 病例进行了横断面描述性研究。患者被分类为轻度至中度、严重和非常严重，并且还标记为幸存者和非幸存者。在亚组中研究了凝血酶原时间 (PT)、国际标准化比值 (INR)、活化部分促凝血酶原激酶时间、D 二聚体、纤维蛋白降解产物 (FDP)、纤维蛋白原和凝血酶时间以及血小板计数。重症患者 (57.62 ± 13.08) 和非幸存者 (56. 54±12.78）。在 3 个亚组和幸存者之间观察到 D 二聚体、FDP、PT、INR 和年龄的统计学显着差异。D 二聚体和 FDP 之间存在强显着正相关（r = 0.838，p  < .001)、PT 和 INR (r = 0.986, p  < 0.001)。根据曲线下面积，D 二聚体是最佳的单一凝血参数（AUC：0.762，p  < 0.001），D 二聚体 + FDP 是 区分轻度中度和重度疾病的最佳组合参数（AUC：0.764， p = 0）。印度人群中 D 二聚体、FDP、PT、PT INR 和更高年龄水平的升高与疾病严重程度和死亡率呈正相关。