Dietary phospholipids have been traditionally known to affect micelle formation. Egg yolk-derived lysophospholipids (LysoPL) are commercially available. We investigated the effects of dietary LysoPL on lymphatic lipid transport. We also compared sn-1 LysoPL and sn-2 LysoPL, which have different fatty acyl esterification positions. Thoracic lymph duct-cannulated rats were fed a diet supplemented with egg yolk-derived sn-1 LysoPL, sn-2 LysoPL, or phospholipids (PL). The amount of lymphatic lipid transport was also evaluated. Time courses of transport were applied to the one-compartment model as one of the pharmacokinetic analyses. The solubility of cholesterol in bile acid micelles was measured. Compared to the PL diet, the sn-1 and sn-2 LysoPL diets significantly reduced the lymphatic transport of cholesterol. There were no differences in the lymphatic PL and TAG transport. There was no difference in cholesterol transport between the sn-1 LysoPL group and the sn-2 LysoPL group; however, the transport rate constant at a decrease in lymphatic cholesterol was lower in the sn-1 LysoPL group than in the sn-2 LysoPL group. Cholesterol solubility in bile acid micelles was significantly decreased in the sn-1 LysoPL and sn-2 LysoPL groups compared to that in the PL group. Dietary LysoPL affects the behavior of intestinal cholesterol and suppresses lymphatic cholesterol transport.

中文翻译：

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与膳食磷脂相比，膳食溶血磷脂降低了胸腔淋巴管插管大鼠的淋巴胆固醇转运

传统上已知膳食磷脂会影响胶束形成。蛋黄衍生的溶血磷脂 (LysoPL) 是可商购的。我们研究了饮食 LysoPL 对淋巴脂质转运的影响。我们还比较了具有不同脂肪酰基酯化位置的sn-1 LysoPL 和sn-2 LysoPL。给胸腔淋巴管插管的大鼠喂食补充有蛋黄衍生的sn-1 LysoPL、sn-2 LysoPL 或磷脂 (PL) 的饮食。还评估了淋巴脂质转运的量。作为药代动力学分析之一，将运输时间过程应用于单室模型。测量胆汁酸胶束中胆固醇的溶解度。与 PL 饮食相比，sn-1和sn-2 LysoPL 饮食显着降低了胆固醇的淋巴转运。淋巴 PL 和 TAG 转运没有差异。sn-1 LysoPL 组和sn-2 LysoPL 组之间的胆固醇转运没有差异；然而， sn-1 LysoPL 组中淋巴胆固醇降低时的转运速率常数低于sn-2 LysoPL 组。胆汁酸胶束中胆固醇溶解度在sn-1 LysoPL 和sn-2中显着降低LysoPL 组与 PL 组相比。膳食 LysoPL 影响肠道胆固醇的行为并抑制淋巴胆固醇的转运。