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Multi-omics analysis of the expression and prognostic value of the butyrophilins in breast cancer
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2021-08-19 , DOI: 10.1002/jlb.5ma0321-158rr
He Ren 1 , Shuliang Li 1, 2, 3 , Xin Liu 1 , Wanjing Li 1 , Jianlei Hao 4, 5 , Na Zhao 1
Affiliation  

Butyrophilins (BTNs) belong to the immunoglobulin superfamily of transmembrane proteins and play a role in the regulation of lymphocyte activation, several autoimmune diseases, and the progression of human cancers. However, the associated clinicopathologic characteristics and prognostic value of BTNs in breast cancer remain unknown. This study aimed to discover potential key related BTN genes and signaling pathways in breast cancer, which could provide new insights for immune-based strategies. In the present study, the mRNA expression level and prognostic value of BTN2A1, BTN3A1, BTN3A2, BTN3A3, BTNL2, BTNL9, ERMAP, and MOG were measured. Up-regulation of these genes was significantly correlated with improved overall and relapse-free survival. We then analyzed the prognostic outcomes of breast cancer subtypes, genetic alterations, interaction networks, and the functional enrichment of eight BTN family genes. Our results showed that these eight genes played essential roles in tumor progression. Furthermore, an immune infiltration analysis indicated that most candidate BTN family members were associated with intratumoral immune cell infiltration, especially that of γδ T cells. Finally, gene set enrichment analysis for a single hub gene revealed that each BTN gene played a vital role in tumor progression through immune signaling pathways. These findings provided new insights into breast cancer pathogenesis and identified eight potential biomarkers for breast cancer.

中文翻译:

嗜乳杆菌蛋白在乳腺癌中的表达及预后价值的多组学分析

Butyrophilins (BTNs) 属于跨膜蛋白的免疫球蛋白超家族,在调节淋巴细胞活化、几种自身免疫性疾病和人类癌症的进展中发挥作用。然而,BTNs 在乳腺癌中的相关临床病理特征和预后价值仍然未知。本研究旨在发现乳腺癌中潜在的关键相关 BTN 基因和信号通路,为基于免疫的策略提供新的见解。在本研究中,BTN2A1BTN3A1BTN3A2BTN3A3BTNL2BTNL9ERMAPMOG的mRNA表达水平和预后价值被测量。这些基因的上调与改善的总体生存率和无复发生存率显着相关。然后我们分析了乳腺癌亚型、遗传改变、相互作用网络和八个 BTN 家族基因的功能丰富的预后结果。我们的结果表明,这八个基因在肿瘤进展中发挥了重要作用。此外,免疫浸润分析表明,大多数候选 BTN 家族成员与肿瘤内免疫细胞浸润有关,尤其是 γδ T 细胞浸润。最后,单个中枢基因的基因集富集分析表明,每个 BTN 基因通过免疫信号通路在肿瘤进展中发挥着至关重要的作用。这些发现提供了对乳腺癌发病机制的新见解,并确定了八种潜在的乳腺癌生物标志物。
更新日期:2021-08-19
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