Graft-versus-host disease (GVHD) is frequent and fatal complication following allogeneic hematopoietic stem cell transplantation (HSCT) and characteristically involves skin, gut, and liver. Macrophages promote tissue regeneration and mediate immunomodulation. Macrophages are divided into two different phenotypes, classically activated M1 (pro-inflammatory or immune-reactive macrophages) and alternatively activated M2 (anti-inflammatory or immune-suppressive macrophages). The anti-inflammatory effect of M2 macrophage led us to test its effect in the pathophysiology of GVHD.

中文翻译：

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供体来源的 M2 巨噬细胞在同种异体造血干细胞移植后减轻 GVHD

移植物抗宿主病 (GVHD) 是异基因造血干细胞移植 (HSCT) 后常见且致命的并发症，其特征是皮肤、肠道和肝脏。巨噬细胞促进组织再生并介导免疫调节。巨噬细胞分为两种不同的表型，经典激活的 M1（促炎或免疫反应巨噬细胞）和交替激活的 M2（抗炎或免疫抑制巨噬细胞）。M2 巨噬细胞的抗炎作用促使我们测试其在 GVHD 病理生理学中的作用。