Myelin-oligodendrocyte glycoprotein antibody-associated disease,The Lancet Neurology

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Myelin-oligodendrocyte glycoprotein antibody-associated disease
The Lancet Neurology ( IF 46.5 ) Pub Date : 2021-08-19 , DOI: 10.1016/s1474-4422(21)00218-0
Romain Marignier ₁ , Yael Hacohen ₂ , Alvaro Cobo-Calvo ₃ , Anne-Katrin Pröbstel ₄ , Orhan Aktas ₅ , Harry Alexopoulos ₆ , Maria-Pia Amato ₇ , Nasrin Asgari ₈ , Brenda Banwell ₉ , Jeffrey Bennett ₁₀ , Fabienne Brilot ₁₁ , Marco Capobianco ₁₂ , Tanuja Chitnis ₁₃ , Olga Ciccarelli ₂ , Kumaran Deiva ₁₄ , Jérôme De Sèze ₁₅ , Kazuo Fujihara ₁₆ , Anu Jacob ₁₇ , Ho Jin Kim ₁₈ , Ingo Kleiter ₁₉ , Hans Lassmann ₂₀ , Maria-Isabel Leite ₂₁ , Christopher Linington ₂₂ , Edgar Meinl ₂₃ , Jacqueline Palace ₂₁ , Friedemann Paul ₂₄ , Axel Petzold ₂₅ , Sean Pittock ₂₆ , Markus Reindl ₂₇ , Douglas Kazutoshi Sato ₂₈ , Krzysztof Selmaj ₂₉ , Aksel Siva ₃₀ , Bruno Stankoff ₃₁ , Mar Tintore ₃ , Anthony Traboulsee ₃₂ , Patrick Waters ₂₁ , Emmanuelle Waubant ₃₃ , Brian Weinshenker ₃₄ , Tobias Derfuss ₄ , Sandra Vukusic ₁ , Bernhard Hemmer ₃₅

Affiliation

Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, and Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hôpital Neurologique Pierre Wertheimer, Bron, France; Centre des Neurosciences de Lyon, INSERM 1028 et CNRS UMR5292, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France.
Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Centre d'Esclerosi Múltiple de Catalunya, Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Neurologic Clinic and Policlinic and Research Center for Clinical Neuroimmunology and Neuroscience, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Medical Faculty, Department of Neurology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Neuroimmunology Unit, Department of Pathophysiology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
IRCCS Fondazione Don Carlo Gnocchi, University of Florence, Florence, Italy.
Institute of Regional Health Research and Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Division of Child Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Neurology and Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Department of Neurology and Department of Ophthalmology, Programs in Neuroscience and Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Brain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Regional Multiple Sclerosis Centre, Department of Neurology, University Hospital San Luigi, Orbassano, Italy.
Department of Pediatric Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, National Referral Center for Rare Inflammatory Brain and Spinal Diseases, Université Paris-Sud, and UMR 1184-CEA-IDMIT, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, France.
Department of Neurology, Strasbourg University Hospital and Clinical Investigation Center, INSERM 1434, Strasbourg, France.
Department of Multiple Sclerosis Therapeutics, Fukushima Medical University School of Medicine Koriyama, Japan; Multiple Sclerosis and Neuromyelitis Optica Center, Southern TOHOKU Research Institute for Neuroscience, Koriyama, Japan.
Division of Multiple Sclerosis and Autoimmune Neurology, Neurological Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; Walton Centre National Health Service Trust, Liverpool, UK.
Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea.
Marianne-Strauß-Klinik, Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg, Germany; Department of Neurology, Ruhr-University Bochum, Bochum, Germany.
Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Institute of Clinical Neuroimmunology, Biomedical Center and University Hospitals, Ludwig Maximilian University Munich, Germany.
NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Moorfields Eye Hospital and National Hospital for Neurology and Neurosurgery, London, UK; University College London Queen Square Institute of Neurology, London, UK; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.
Department of Neurology and Laboratory Medicine and Pathology, and Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Brain Institute of Rio Grande do Sul and School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
University of Warmia and Mazury, Olsztyn, Poland; Center of Neurology, Łódź, Poland.
Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of Neurology, Istanbul, Turkey.
Sorbonne Université, Paris Brain Institute, ICM, CNRS, Inserm, and Saint Antoine Hospital, APHP, Paris, France.
Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Department of Neurology and Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany.

Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently identified autoimmune disorder that presents in both adults and children as CNS demyelination. Although there are clinical phenotypic overlaps between MOGAD, multiple sclerosis, and aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder (NMOSD) cumulative biological, clinical, and pathological evidence discriminates between these conditions. Patients should not be diagnosed with multiple sclerosis or NMOSD if they have anti-MOG antibodies in their serum. However, many questions related to the clinical characterisation of MOGAD and pathogenetic role of MOG antibodies are still unanswered. Furthermore, therapy is mainly based on standard protocols for aquaporin-4 antibody-associated NMOSD and multiple sclerosis, and more evidence is needed regarding how and when to treat patients with MOGAD.

中文翻译：

髓鞘少突胶质细胞糖蛋白抗体相关疾病

髓鞘少突胶质细胞糖蛋白抗体相关疾病 (MOGAD) 是一种最近发现的自身免疫性疾病，在成人和儿童中表现为中枢神经系统脱髓鞘。尽管 MOGAD、多发性硬化症和水通道蛋白 4 抗体相关的视神经脊髓炎谱系障碍 (NMOSD) 之间存在临床表型重叠，但累积的生物学、临床和病理学证据可区分这些疾病。如果患者血清中含有抗 MOG 抗体，则不应被诊断为多发性硬化症或 NMOSD。然而，与 MOGAD 的临床特征和 MOG 抗体的致病作用相关的许多问题仍未得到解答。此外，治疗主要基于水通道蛋白 4 抗体相关 NMOSD 和多发性硬化症的标准方案，

更新日期：2021-08-19

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