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Occupational exposures in PET procedures with 18F-FDG in adult and pediatric patients
Radiation Physics and Chemistry ( IF 2.9 ) Pub Date : 2021-08-18 , DOI: 10.1016/j.radphyschem.2021.109744
Walmir Belinato 1 , Gessica da Silva Pereira 1 , William S. Santos 2 , Lucio P. Neves 2, 3 , Ana P. Perini 2, 3 , Divanizia N. Souza 4
Affiliation  

Diagnosis through positron emission tomography (PET) is an increasingly used procedure in cerebral, cardiac and especially oncology diseases. It is performed in nuclear medicine clinics, mainly using 18F-Fluorodeoxyglucose (18F-FDG), which has one of the longest half-lives among positron emitters. The gamma rays, produced in the annihilations, require strict radiation control to guarantee the safety of the occupationally exposed individuals working in PET exam facilities. To evaluate occupational exposures, in this study, the MCNPX2.7.0 radiation transport code was used. The professionals were represented by the FASH3 (female) and MASH3 (male) adult virtual anthropomorphic phantoms, which have anthropometric characteristics like those of real individuals. Four exposure scenarios were modeled: radiopharmaceutical preparation, administration to the patient, patient follow-up, and patient placement in PET equipment. The results are presented in terms of the mean effective dose by PET procedure (μSv/procedure) and the mean effective dose by radiopharmaceutical activity (nSv/MBq). Using the set of conversion coefficients presented in this study, it is possible to calculate the absolute values of effective doses for nuclear medicine professionals who are in contact with the radioactive material or the patient. The differences between our study and the literature were only 3%. The effective occupational doses, with an adult patient, were 14% higher than those with pediatric patients.



中文翻译:

成人和儿童患者 18F-FDG PET 手术中的职业暴露

通过正电子发射断层扫描 (PET) 进行诊断是越来越多地用于脑、心脏,尤其是肿瘤疾病的诊断方法。它在核医学诊所进行,主要使用 18F-氟脱氧葡萄糖 (18F-FDG),它是正电子发射体中半衰期最长的物质之一。湮灭中产生的伽马射线需要严格的辐射控制,以保证在 PET 检查设施中工作的职业暴露人员的安全。为了评估职业暴露,在本研究中,使用了 MCNPX2.7.0 辐射传输代码。专业人士以 FASH3(女性)和 MASH3(男性)成人虚拟拟人幻影为代表,它们具有与真实个体相似的人体测量特征。模拟了四种暴露场景:放射性药物制备、对患者进行给药、患者随访和患者放置在 PET 设备中。结果以 PET 程序的平均有效剂量 (μSv/程序) 和放射性药物活性的平均有效剂量 (nSv/MBq) 表示。使用本研究中提出的一组转换系数,可以计算与放射性物质或患者接触的核医学专业人员的有效剂量的绝对值。我们的研究与文献之间的差异仅为 3%。成人患者的有效职业剂量比儿科患者高 14%。结果以 PET 程序的平均有效剂量 (μSv/程序) 和放射性药物活性的平均有效剂量 (nSv/MBq) 表示。使用本研究中提出的一组转换系数,可以计算与放射性物质或患者接触的核医学专业人员的有效剂量的绝对值。我们的研究与文献之间的差异仅为 3%。成人患者的有效职业剂量比儿科患者高 14%。结果以 PET 程序的平均有效剂量 (μSv/程序) 和放射性药物活性的平均有效剂量 (nSv/MBq) 表示。使用本研究中提出的一组转换系数,可以计算与放射性物质或患者接触的核医学专业人员的有效剂量的绝对值。我们的研究与文献之间的差异仅为 3%。成人患者的有效职业剂量比儿科患者高 14%。我们的研究与文献之间的差异仅为 3%。成人患者的有效职业剂量比儿科患者高 14%。我们的研究与文献之间的差异仅为 3%。成人患者的有效职业剂量比儿科患者高 14%。

更新日期:2021-08-24
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