Novel ketogenic diet formulation improves sucrose-induced insulin resistance in canton strain Drosophila melanogaster,Journal of Food Biochemistry

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Novel ketogenic diet formulation improves sucrose-induced insulin resistance in canton strain Drosophila melanogaster
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-08-18 , DOI: 10.1111/jfbc.13907
Omowumi T Kayode ₁ , Damilare Rotimi ₂ , Elizabeth Okoh ₂ , Matthew Iyobhebhe ₂ , Abolanle A A Kayode ₃ , Oluwafemi Adeleke Ojo ₂

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This study investigates the antidiabetic effect of a ketogenic diet (KD) on sucrose-induced insulin resistance in the fruit fly model. The fruit flies were divided and grouped into four: Group A, B, C, and D, representing the control, high-sucrose diet (HSD), KD, and HSD + KD, respectively. The administration of the various treatments to the groups proceeded for 7 days. The flies were thereafter immobilized, homogenized, and the homogenates used for biochemical parameters determination. This includes glucose concentration, antioxidant status, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, total cholesterol (TC), triglycerides (TG), and protein concentration. There was a significant increase (p < .05) in weight gain, glucose concentration, TG, HMG-CoA reductase activity, TC, and lipid peroxidation status of the HSD group compared with the control and KD groups. The antioxidant enzymes measured (superoxide dismutase, catalase, and reduced glutathione) and protein concentrations were repressed significantly (p < .05) in the HD groups but significantly elevated (p < .05) in the KD, HSD + KD, and the control groups. The KD improved biochemical parameters altered during the onset of sucrose-induced insulin resistance. With further research on this, KD may emerge as the much-awaited treatment option for diabetes mellitus type 2 (T2DM) with almost reduced toxicity concerns.

中文翻译：

新型生酮饮食配方可改善黑腹果蝇的蔗糖诱导的胰岛素抵抗

本研究调查了生酮饮食 (KD) 对果蝇模型中蔗糖诱导的胰岛素抵抗的抗糖尿病作用。果蝇被分为四组：A、B、C 和 D 组，分别代表对照、高糖饮食 (HSD)、KD 和 HSD + KD。对各组进行各种治疗持续7天。然后将苍蝇固定、匀浆，匀浆用于生化参数测定。这包括葡萄糖浓度、抗氧化状态、3-羟基-3-甲基戊二酰辅酶 A (HMG-CoA) 还原酶、总胆固醇 (TC)、甘油三酯 (TG) 和蛋白质浓度。显着增加（p < .05) 与对照组和 KD 组相比，HSD 组的体重增加、葡萄糖浓度、TG、HMG-CoA 还原酶活性、TC 和脂质过氧化状态。抗氧化酶（超氧化物歧化酶、过氧化氢酶和还原型谷胱甘肽）和蛋白质浓度在 HD 组中被显着抑制 ( p < .05)，但在 KD、HSD + KD 和对照中显着升高 ( p < .05)组。KD 改善了在蔗糖诱导的胰岛素抵抗发作期间改变的生化参数。随着对此的进一步研究，KD 可能成为期待已久的 2 型糖尿病 (T2DM) 治疗选择，几乎可以减少毒性问题。

更新日期：2021-09-06

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