Various studies have reported that young European women are more likely to develop early-onset periodontitis compared to men. A potential explanation for the observed variations in sex and age of disease onset is the natural genetic variation within the autosomal genomes. We hypothesized that genotype-by-sex (G × S) interactions contribute to the increased prevalence and severity.

中文翻译：

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性别特异性遗传因素影响欧洲人患早发性牙周炎的风险

各种研究报告说，与男性相比，年轻的欧洲女性更容易患上早发性牙周炎。观察到的发病性别和发病年龄差异的一个潜在解释是常染色体基因组内的自然遗传变异。我们假设不同性别的基因型（G × S）相互作用导致患病率和严重程度增加。