MicroRNAs (miRNAs) are a group of endogenous, small (∼22 nts in length) noncoding RNA molecules that function specifically by base pairing with the mRNA of genes and regulate gene expression at the post-transcriptional level. Alterations in miR-32 expression have been found in numerous diseases and shown to play a vital role in cell proliferation, apoptosis, oncogenesis, invasion, metastasis and drug resistance. MiR-32 has been documented as an oncomiR in the majority of related studies but has been also verified as a tumour suppressor miRNA in conflicting reports. Moreover, it has a crucial role in metabolic and cardiovascular disorders. This review provides an in-depth look into the most recent finding regarding miR-32, which is involved in the expression, regulation and functions in different diseases, especially tumours. Additionally, this review outlines novel findings suggesting that miR-32 may be useful as a noninvasive biomarker and as a targeted therapeutic in several diseases.

中文翻译：

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microRNA-32的神奇与神秘


MicroRNA (miRNA) 是一组内源性小（长度约 22 nt）非编码 RNA 分子，通过与基因 mRNA 碱基配对来特异性发挥作用，并在转录后水平调节基因表达。 miR-32 表达的改变已在多种疾病中被发现，并被证明在细胞增殖、凋亡、肿瘤发生、侵袭、转移和耐药性中发挥着至关重要的作用。 MiR-32 在大多数相关研究中已被记录为 oncomiR，但在相互矛盾的报告中也被证实为肿瘤抑制 miRNA。此外，它在代谢和心血管疾病中起着至关重要的作用。本综述深入探讨了有关 miR-32 的最新发现，miR-32 参与不同疾病（尤其是肿瘤）的表达、调控和功能。此外，这篇综述概述了新的发现，表明 miR-32 可能可用作非侵入性生物标志物和多种疾病的靶向治疗。