The purpose of this paper is to explore the possible mechanisms of anti-inflammatory and scar repair by Mongolian horse oil. We used TCM database and literature mining to collect active compounds of horse oil and used Swiss TargetPrediction and SuperPred server to find targets of compounds. Anti-inflammatory drug targets were collected through the CTD database. Go annotation of targets and KEGG pathway were enriched and analyzed through Metascape database platform. Molecular docking between active ingredients and targets was verified by AutoDock software. Metascape analysis revealed that the key candidate targets were significantly enriched in a number of pathways associated with inflammatory pathology. The results of molecular docking showed that oleic acid, a major component of animals oil, could influence the regulatory functions of TNF, NGF, IL6, IL1B, Jun, and CDK1. This suggests that animals oil can regulate the development of inflammation through its active ingredient, oleic acid, and can influence the expression of multiple signaling pathways, with theoretical endogenous interactions with TNF, NGF, IL6, IL1B, JUN, and CDK1 proteins.

本文旨在探讨蒙古马油抗炎和修复疤痕的可能机制。我们使用TCM数据库和文献挖掘来收集马油的活性化合物，并使用Swiss TargetPrediction和SuperPred服务器寻找化合物的目标。通过CTD数据库收集抗炎药物靶点。通过Metascape数据库平台丰富和分析了目标的Go注释和KEGG通路。AutoDock 软件验证了活性成分和靶标之间的分子对接。Metascape 分析显示，关键候选靶标在与炎症病理学相关的许多通路中显着富集。分子对接结果表明，动物油的主要成分油酸可影响TNF、NGF、IL6、IL1B、Jun 和 CDK1。这表明动物油可以通过其活性成分油酸调节炎症的发展，并可以影响多种信号通路的表达，理论上与 TNF、NGF、IL6、IL1B、JUN 和 CDK1 蛋白存在内源性相互作用。