BACKGROUND: Patients discharged after COVID-19 report ongoing needs.

OBJECTIVES: To measure incident symptoms after COVID-19 hospitalization.

DESIGN, SETTING, AND PARTICIPANTS: Preplanned early look at 1-month follow-up surveys from patients hospitalized August 2020 to January 2021 in NHLBI PETAL Network’s Biology and Longitudinal Epidemiology: COVID-19 Observational (BLUE CORAL) study. English- or Spanish-speaking hospitalized adults without substantial pre-COVID-19 disability with a positive molecular test for SARS-CoV-2.

RESULTS: Overall, 253 patients were hospitalized for a median of 5 days (interquartile range [IQR], 3-8), and had a median age of 60 years (IQR, 45-68). By race/ethnicity, 136 (53.8%) were non-Hispanic White, 23 (9.1%) were non-Hispanic Black, and 83 (32.8%) were Hispanic. Most (139 [54.9%]) reported a new or worsened cardiopulmonary symptom, and 16% (n = 39) reported new or increased oxygen use; 213 (84.2%) patients reported not feeling fully back to their pre-COVID-19 level of functioning. New limitations in activities of daily living were present in 130 (52.8%) patients. Financial toxicities, including job loss or change (49 [19.8%]), having a loved one take time off (93 [37.8%]), and using up one’s savings (58 [23.2%]), were common. Longer lengths of hospital stay were associated with greater odds of 1-month cardiopulmonary symptoms (adjusted odds ratio [aOR], 1.82 per additional week in the hospital; 95% CI, 1.11-2.98) and new disability (aOR, 2.06; 95% CI, 1.21-3.53). There were not uniform demographic patterns of association.

LIMITATIONS: We prioritized patients’ reports of their own incident problems over objective testing.

CONCLUSION: Patients who survived COVID-19 in the United States during late 2020/early 2021 still faced new burdens 1 month after hospital discharge.

背景： COVID-19 后出院的患者报告了持续的需求。

目的：测量 COVID-19 住院后的事件症状。

设计、设置和参与者：在 NHLBI PETAL Network 的生物学和纵向流行病学：COVID-19 观察性（蓝珊瑚）研究中，预先计划对 2020 年 8 月至 2021 年 1 月住院患者的 1 个月随访调查进行早期观察。讲英语或西班牙语的住院成人，在 COVID-19 之前没有实质性残疾，且 SARS-CoV-2 分子检测呈阳性。

结果：总体而言，253 名患者住院的中位时间为 5 天（四分位距 [IQR]，3-8），中位年龄为 60 岁（IQR，45-68）。按种族/民族划分，136 人（53.8%）为非西班牙裔白人，23 人（9.1%）为非西班牙裔黑人，83 人（32.8%）为西班牙裔。大多数 (139 [54.9%]) 报告了新的或恶化的心肺症状，16% (n = 39) 报告了新的或增加的氧气使用；213 名 (84.2%) 患者报告说感觉没有完全恢复到 COVID-19 之前的功能水平。130 名 (52.8%) 患者出现了新的日常生活活动受限。财务问题很常见，包括失业或变动 (49 [19.8%])、爱人请假 (93 [37.8%]) 和用完自己的积蓄 (58 [23.2%])。住院时间更长与 1 个月心肺症状（调整后的比值比 [aOR]，1.82 每增加一周住院时间；95% CI，1.11-2.98）和新的残疾（aOR，2.06；95% CI，1.21-3.53）。没有统一的人口统计模式。

局限性：我们优先考虑患者对自身事件问题的报告，而不是客观测试。

结论： 2020 年末/2021 年初在美国幸存的 COVID-19 患者在出院后 1 个月仍面临新的负担。