Recently, intense efforts have been dedicated to the development of novel synthetic strategies to access aromatic amines due to their importance in the pharmaceuticals, agrochemicals, materials, and natural product areas. Although numerous transition-metal-catalyzed C–N formation strategies have been described for the preparation of aromatic amines in the past few decades, complementary methods under transition-metal-free conditions are still required. We present the recent advances in the exploration of innovative amination approaches via C(sp²)–O/C(sp²)–S bond cleavage in this review.

1 Introduction

2 Stoichiometric Base-Promoted Amination

3 Base-Catalyzed Amination

4 Photoredox-Catalyzed Amination

5 Acid-Promoted Amination

6 Conclusion and Perspectives

最近，由于芳香胺在药物、农用化学品、材料和天然产物领域的重要性，人们致力于开发新的合成策略以获取芳香胺。尽管在过去的几十年中已经描述了许多用于制备芳香胺的过渡金属催化的 C-N 形成策略，但仍然需要在无过渡金属条件下的补充方法。我们在这篇综述中介绍了通过 C(sp ² )–O/C(sp ² )–S 键裂解探索创新胺化方法的最新进展。

1 简介

2 化学计量的碱促进胺化

3 碱催化胺化

4 光氧化还原催化胺化

5 酸促进胺化

6 结论与展望