Generalized verrucosis is a clinical manifestation of human papillomavirus infection. Patients with generalized verrucosis present with over 20 verrucae distributed over various anatomical sites. The disorder occurs in association with several genetic syndromes with immunodeficiency, including GATA2 deficiency. We report a 12-year-old boy with GATA2 deficiency and generalized verrucosis that worsened after cyclosporine use following bone marrow transplant. Systemic treatment with acitretin and topical application of trichloroacetic acid, likely along with immune reconstitution, led to complete remission.

中文翻译：

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全身性阿维A和三氯乙酸成功治疗GATA2缺陷的全身性疣病

全身性疣病是人乳头瘤病毒感染的临床表现。全身性疣病患者存在超过 20 个分布在不同解剖部位的疣。这种疾病与几种免疫缺陷的遗传综合征有关，包括 GATA2 缺陷。我们报告了一名患有 GATA2 缺乏症和全身性疣病的 12 岁男孩，在骨髓移植后使用环孢素后病情恶化。用阿维A 进行全身治疗和局部应用三氯乙酸，可能与免疫重建一起，导致完全缓解。