Recent evidence relates the inflammatory system to the aetiology and evolution of mood disorders. The Neutrophil-Lymphocyte Ratio (NLR) is an affordable and reproducible biomarker of inflammation. The aim of the study is to retrospectively evaluate the association between NLR and response to treatment in 50 patients aged over 50 with a diagnosis of Psychotic Depression (PD) who were admitted to an acute psychiatric unit between 2010 and 2018. They were stratified according to sex and treatment received: antidepressants, antipsychotics and electroconvulsive therapy (ECT). The NLR was collected on admission and the clinical response was quantified by the Global Assessment of Functioning (GAF) scale. In the simple linear regression, high NLR upon admission was associated with better clinical response during hospitalization as measured by GAF. When stratifying the patients, this association was maintained in women, in patients who received antidepressant treatment with tricyclics and SNRIs, antipsychotic treatment with olanzapine/quetiapine and those who did not receive ECT. NLR is an accessible biomarker in clinical practice, and in PD patients it could guide the therapeutic strategy and be a predictor of response.

最近的证据将炎症系统与情绪障碍的病因和演变联系起来。中性粒细胞-淋巴细胞比率 (NLR) 是一种负担得起且可重复的炎症生物标志物。该研究的目的是回顾性评估 2010 年至 2018 年间入住急性精神病科的 50 名 50 岁以上的精神病性抑郁症 (PD) 患者的 NLR 与治疗反应之间的关联。性别和接受的治疗：抗抑郁药、抗精神病药和电休克疗法 (ECT)。NLR 在入院时收集，临床反应通过全球功能评估 (GAF) 量表量化。在简单的线性回归中，根据 GAF 测量，入院时的高 NLR 与住院期间更好的临床反应相关。在对患者进行分层时，这种关联在女性、接受三环类药物和 SNRIs 抗抑郁治疗的患者、接受奥氮平/喹硫平抗精神病治疗的患者以及未接受 ECT 的患者中保持不变。NLR 是临床实践中可及的生物标志物，在 PD 患者中，它可以指导治疗策略并预测反应。