当前位置：
X-MOL 学术
›
Chem. Soc. Rev.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Broadening of horizons in the synthesis of CD3-labeled molecules
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2021-08-19 , DOI: 10.1039/d1cs00544h Qiao Sun 1 , Jean-François Soulé 2
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2021-08-19 , DOI: 10.1039/d1cs00544h Qiao Sun 1 , Jean-François Soulé 2
Affiliation
|
In the light of the recent potentials of deuterated molecules as pharmaceuticals or even in mechanistic understanding, efficient methods for their synthesis are continually desired. CD3-containing molecules are prominent amongst these motifs due to the parallel of the “magic methyl effect”: introducing a methyl group into pharmaceuticals could positively affect biological activities. The trideuteromethyl group is bound to molecules either by C, N, O, or S atom. For a long time, the preparation methods of such labeled compounds were underestimated and involved multi-step syntheses. More recently, specific approaches dealing with the direct incorporation of the CD3 group have been developed. This Review gives an overview of the methods for the preparation of CD3-labeled molecules from conventional functional group interconversion techniques to catalytic approaches and include radical strategy. Detailed reaction mechanisms are also discussed.
中文翻译：
拓宽 CD3 标记分子合成的视野
鉴于最近氘化分子作为药物的潜力，甚至在机理上的理解，不断需要有效的合成方法。由于“神奇的甲基效应”的相似性，包含CD 3的分子在这些基序中很突出：将甲基引入药物可以对生物活性产生积极影响。三氘代甲基通过 C、N、O 或 S 原子与分子结合。长期以来，此类标记化合物的制备方法被低估并涉及多步合成。最近，已经制定了处理直接纳入 CD 3小组的具体方法。本评论概述了准备 CD 3 的方法- 从传统官能团互变技术到催化方法的标记分子，包括自由基策略。还讨论了详细的反应机制。
更新日期：2021-08-19
中文翻译：
拓宽 CD3 标记分子合成的视野
鉴于最近氘化分子作为药物的潜力，甚至在机理上的理解，不断需要有效的合成方法。由于“神奇的甲基效应”的相似性，包含CD 3的分子在这些基序中很突出：将甲基引入药物可以对生物活性产生积极影响。三氘代甲基通过 C、N、O 或 S 原子与分子结合。长期以来，此类标记化合物的制备方法被低估并涉及多步合成。最近，已经制定了处理直接纳入 CD 3小组的具体方法。本评论概述了准备 CD 3 的方法- 从传统官能团互变技术到催化方法的标记分子，包括自由基策略。还讨论了详细的反应机制。
京公网安备 11010802027423号