Infection with Toxoplasma gondii (T. gondii) during the pregnant period and its potentially miserable outcomes for the fetus, newborn, and even adult offspring continuously occur worldwide. People acquire infection through the consumption of infected and undercooked meat or contaminated food or water. T. gondii infection in pregnant women primarily during the gestation causes microcephaly, mental and psychomotor retardation, or death. Abnormal pregnancy outcomes are mainly associated with regulatory T cell (Treg) dysfunction. Tregs, a special subpopulation of T cells, function as a vital regulator in maintaining immune homeostasis. Tregs exert a critical effect on forming and maintaining maternal-fetal tolerance and promoting fetal development during the pregnancy period. Forkhead box P3 (Foxp3), a significant functional factor of Tregs, determines the status of Tregs. In this review, we summarize the effects of T. gondii infection on host Tregs and its critical transcriptional factor, Foxp3.

中文翻译：

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调节性 T 细胞在弓形虫诱导的不良妊娠结局中的作用和功能

怀孕期间感染弓形虫( T. gondii ) 及其对胎儿、新生儿甚至成年后代的潜在悲惨后果在世界范围内不断发生。人们通过食用受感染和未煮熟的肉类或受污染的食物或水而感染。刚地弓形虫孕妇感染主要在妊娠期导致小头​​畸形、精神和精神运动迟缓或死亡。异常妊娠结局主要与调节性 T 细胞 (Treg) 功能障碍有关。Tregs 是一种特殊的 T 细胞亚群，在维持免疫稳态方面发挥着重要调节作用。Tregs 在孕期对形成和维持母胎耐受性和促进胎儿发育发挥关键作用。Forkhead box P3（Foxp3）是Tregs的重要功能因素，决定了Tregs的状态。在这篇综述中，我们总结了弓形虫感染对宿主 Tregs 及其关键转录因子 Foxp3 的影响。