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A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems
Journal of Chemistry ( IF 2.8 ) Pub Date : 2021-08-18 , DOI: 10.1155/2021/6659106
Thuc Ngoc Dinh 1 , Mai Vu Thi Ha 1 , Luong Ngo Xuan 2 , Huan Trinh Thi 2 , Huong Nguyen Thi 2 , Mai Nguyen Thi Ngoc 2 , Giap Tran Huu 3 , Oanh Vu Thi Kim 3 , Thanh Le Nguyen 3
Affiliation  

Phytochemical study of Rourea oligophlebia stems led to the isolation of a new 2-pyrrolidone alkaloid (R,S)-N-(5-hydroxyl-pyrrolidin-2-one-1-yl)acetamide (1), together with 14 known compounds including friedelin (2), friedanol (3), taraxerol (4), vanillin (5), coniferyl aldehyde (6), apigenin (7), 7α-hydroxy-3β-sitosterol (8), coniferyl alcohol (9), scopoletin (10), emodin (11), protocatechuic acid (12), catechin (13), procyanidin A1 (14), and (E)-2,3,5,4’-tetrahydroxystilbene-2-β-D-glucoside (15). Several isolated compounds were evaluated for cytotoxicity and antimicrobial activity. Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. Compounds 6 and 810 showed selective activity on HepG-2 and MCF-7 over KB and LU cancer cell lines, while compound 7 exhibited similar effects on KB, HepG-2, and MCF-7 cell lines with IC50 values of 36.46 ± 0.81, 32.00 ± 0.58, and 32.03 ± 0.61 µg/mL, respectively.

中文翻译:

来自 Rourea oligophlebia 茎的一种新的吡咯烷酮生物碱和其他成分

Rourea oligophlebia茎的植物化学研究导致分离出一种新的 2-吡咯烷酮生物碱 ( R , S )- N -(5-hydroxyl-pyrrolidin-2-one-1-yl) 乙酰胺 ( 1 ),以及 14 种已知化合物包括木栓(2),friedanol(3),蒲公英赛醇(4),香草醛(5),松柏醛(6),芹菜素(7),7 α -羟基-3 β谷甾醇(8),松柏醇(9) , 东莨菪碱 ( 10 ), 大黄素 ( 11 ), 原儿茶酸 (12 )、儿茶素( 13 )、原花青素A1( 14 )和( E )-2,3,5,4'-四羟基二苯乙烯-2- β -D-葡萄糖苷( 15 )。评估了几种分离的化合物的细胞毒性和抗菌活性。化合物11对革兰氏 (+) 菌株表现出良好的抗菌活性,对 KB、Hep-G2 和 LU 癌细胞系具有中等的细胞毒性。化合物6810对 HepG-2 和 MCF-7 显示出对 KB 和 LU 癌细胞系的选择性活性,而化合物7对 KB、HepG-2 和 MCF-7 细胞系表现出相似的作用,IC 50值分别为 36.46 ± 0.81、32.00 ± 0.58 和 32.03 ± 0.61  µ g/mL。
更新日期:2021-08-19
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