Physicochemical and in Vitro Antibacterial Evaluation of Metronidazole Loaded Eudragit S-100 Nanofibrous Mats for the Intestinal Drug Delivery,Advanced Fiber Materials

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Physicochemical and in Vitro Antibacterial Evaluation of Metronidazole Loaded Eudragit S-100 Nanofibrous Mats for the Intestinal Drug Delivery
Advanced Fiber Materials ( IF 17.2 ) Pub Date : 2021-08-16 , DOI: 10.1007/s42765-021-00090-y
Priyanka P. Rade _{1,

2} , Prabhanjan S. Giram _{1,

2} , Baijayantimala Garnaik _{1,

2} , Ajinkya A. Shitole ₃ , Neeti Sharma ₃

Affiliation

Abstract

Metronidazole (MTZ) loaded Eudragit S-100 (ES-100) nonwoven nanofibrous mats were successfully electrospun and evaluated for intestinal drug delivery. MTZ was varied in the range of 1–15% (w/w) in ES-100 nanofibrous mats, the morphological characterization of nanofibrous mats was carried out using FE-SEM and the average diameter of nanofiber was found in the range 150–600 nm. WAXD and DSC demonstrated the amorphous nature of MTZ in ES-100 nanofibrous mats. Their contact angle analysis confirmed the hydrophobic nature. The mechanical strength of ES-100 nanofibrous mats decreased with increasing MTZ concentration. The drug release profiles showed 74% MTZ release from ES-100d within 2 h at pH 6.8 which is the colonic environment. Antibacterial activities against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli) showed that the ES-100 nanofibrous mats loaded with MTZ exhibited good activity.

Graphic abstract

中文翻译：

用于肠道给药的甲硝唑 Eudragit S-100 纳米纤维垫的物理化学和体外抗菌评价

摘要

装载甲硝唑 (MTZ) 的 Eudragit S-100 (ES-100) 非织造纳米纤维垫成功电纺并评估肠道药物递送。ES-100 纳米纤维垫中的 MTZ 在 1-15% (w/w) 范围内变化，纳米纤维垫的形态特征使用 FE-SEM 进行，纳米纤维的平均直径在 150-600 范围内纳米。WAXD 和 DSC 证明了 ES-100 纳米纤维垫中 MTZ 的无定形性质。它们的接触角分析证实了疏水性。ES-100 纳米纤维垫的机械强度随着 MTZ 浓度的增加而降低。药物释放曲线显示，在结肠环境 pH 6.8 下，ES-100d 在 2 小时内释放 74% MTZ。对革兰氏阳性菌（金黄色葡萄球菌）的抗菌活性) 和革兰氏阴性菌 (大肠杆菌) 表明负载 MTZ 的 ES-100 纳米纤维垫表现出良好的活性。

图形摘要

更新日期：2021-08-19

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