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Synthesis, Mechanism Elucidation and Biological Insights of Tellurium(IV)-Containing Heterocycles
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2021-08-18 , DOI: 10.1002/chem.202102287 Leandro Piovan 1 , João Pedro A. Souza 2 , Pamela T. Bandeira 2 , Leociley R. A. Menezes 2 , Mateus B. Bespalhok 2 , Débora B. Scariot 3 , Francielle P. Garcia 3 , Siddhartha O. K. Giese 4 , David L. Hughes 5 , Celso V. Nakamura 3 , Andersson Barison 4 , Alfredo R. M. Oliveira 4 , Renan B. Campos 6
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2021-08-18 , DOI: 10.1002/chem.202102287 Leandro Piovan 1 , João Pedro A. Souza 2 , Pamela T. Bandeira 2 , Leociley R. A. Menezes 2 , Mateus B. Bespalhok 2 , Débora B. Scariot 3 , Francielle P. Garcia 3 , Siddhartha O. K. Giese 4 , David L. Hughes 5 , Celso V. Nakamura 3 , Andersson Barison 4 , Alfredo R. M. Oliveira 4 , Renan B. Campos 6
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In the search for bioactive organotellurium compounds, promising hypervalent TeIV-containing heterocycles with possible biological applications have been obtained. 125Te NMR of a series of 16 halogenated organotelluranes confirms that these products contain a Te−O bond within the five- or six-membered ring. We describe their synthesis, identification of the most favorable mechanism and diastereoselectivity, stability assays and in vitro potential against L. amazonensis.
中文翻译：
含碲 (IV) 杂环的合成、机理阐明和生物学见解
在寻找具有生物活性的有机碲化合物的过程中，已经获得了具有可能的生物学应用的有前景的含Te IV的高价杂环。一系列 16 卤化有机四氢呋喃的125 Te NMR 证实这些产品在五元环或六元环内含有 Te-O 键。我们描述了它们的合成、最有利机制的鉴定和非对映选择性、稳定性测定和体外抗亚马逊乳杆菌的潜力。
更新日期：2021-10-19
中文翻译：
含碲 (IV) 杂环的合成、机理阐明和生物学见解
在寻找具有生物活性的有机碲化合物的过程中，已经获得了具有可能的生物学应用的有前景的含Te IV的高价杂环。一系列 16 卤化有机四氢呋喃的125 Te NMR 证实这些产品在五元环或六元环内含有 Te-O 键。我们描述了它们的合成、最有利机制的鉴定和非对映选择性、稳定性测定和体外抗亚马逊乳杆菌的潜力。
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