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Synthesis, Mechanism Elucidation and Biological Insights of Tellurium(IV)-Containing Heterocycles
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2021-08-18 , DOI: 10.1002/chem.202102287
Leandro Piovan 1 , João Pedro A. Souza 2 , Pamela T. Bandeira 2 , Leociley R. A. Menezes 2 , Mateus B. Bespalhok 2 , Débora B. Scariot 3 , Francielle P. Garcia 3 , Siddhartha O. K. Giese 4 , David L. Hughes 5 , Celso V. Nakamura 3 , Andersson Barison 4 , Alfredo R. M. Oliveira 4 , Renan B. Campos 6
Affiliation  

In the search for bioactive organotellurium compounds, promising hypervalent TeIV-containing heterocycles with possible biological applications have been obtained. 125Te NMR of a series of 16 halogenated organotelluranes confirms that these products contain a Te−O bond within the five- or six-membered ring. We describe their synthesis, identification of the most favorable mechanism and diastereoselectivity, stability assays and in vitro potential against L. amazonensis.
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中文翻译:

含碲 (IV) 杂环的合成、机理阐明和生物学见解

在寻找具有生物活性的有机碲化合物的过程中,已经获得了具有可能的生物学应用的有前景的含Te IV的高价杂环。一系列 16 卤化有机四氢呋喃的125 Te NMR 证实这些产品在五元环或六元环内含有 Te-O 键。我们描述了它们的合成、最有利机制的鉴定和非对映选择性、稳定性测定和体外抗亚马逊乳杆菌的潜力。
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更新日期:2021-10-19
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