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Sesamin exerts anti-tumor activity in esophageal squamous cell carcinoma via inhibition of TRIM44 and NF-κB signaling
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2021-08-19 , DOI: 10.1111/cbdd.13937 Linchun Wen 1, 2 , Weimin Mao 1 , Lu Xu 2 , Beibei Cai 2 , Liying Gu 2
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2021-08-19 , DOI: 10.1111/cbdd.13937 Linchun Wen 1, 2 , Weimin Mao 1 , Lu Xu 2 , Beibei Cai 2 , Liying Gu 2
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Tripartite motif-containing 44 (TRIM44) is known to play an oncogenic role in multiple human cancers, including esophageal cancer. Sesamin possesses potent anti-inflammatory and anti-cancer properties for various cancers. This study is designed to unravel the biological functions of sesamin and TRIM44 in esophageal cancer. TRIM44 expression in esophageal squamous cell cancer (ESCC) cell lines and tissues was determined by RT-qPCR assay and Western blot. The effects of sesamin and TRIM44 on ESCC cell growth in vivo and in vitro were assessed by the mouse model and CCK-8 assay, respectively. We found that TRIM44 was significantly upregulated in ESCC cell lines and tissues when compared to their counterparts. Sesamin treatment or depletion of TRIM44 markedly reduced ESCC cell proliferation. The nuclear factor kappa B (NF-κB) and toll-like receptor 4 (TLR4) signaling pathway may be involved in sesamin-mediated TRIM44 suppression. Finally, we showed that oral administration of sesamin dramatically inhibited tumor growth or ESCC in nude mice. Our results suggest that sesamin exerts anti-tumor activity in ESCC via inhibition of NF-κB signaling pathway, demonstrating its potential for the treatment of esophageal cancer.
中文翻译：
芝麻素通过抑制 TRIM44 和 NF-κB 信号传导在食管鳞状细胞癌中发挥抗肿瘤活性
已知含有三方基序的 44 (TRIM44) 在包括食道癌在内的多种人类癌症中发挥致癌作用。芝麻素对各种癌症具有有效的抗炎和抗癌特性。本研究旨在揭示芝麻素和 TRIM44 在食管癌中的生物学功能。通过 RT-qPCR 测定和蛋白质印迹测定食管鳞状细胞癌 (ESCC) 细胞系和组织中的 TRIM44 表达。分别通过小鼠模型和CCK-8测定评估芝麻素和TRIM44对体内和体外ESCC细胞生长的影响。我们发现与对应物相比，TRIM44 在 ESCC 细胞系和组织中显着上调。芝麻素处理或TRIM44的消耗显着降低了ESCC细胞增殖。核因子 kappa B (NF-κB) 和 toll 样受体 4 (TLR4) 信号通路可能参与芝麻素介导的 TRIM44 抑制。最后，我们发现口服芝麻素可显着抑制裸鼠的肿瘤生长或 ESCC。我们的研究结果表明，芝麻素通过抑制 NF-κB 信号通路在 ESCC 中发挥抗肿瘤活性，证明了其治疗食管癌的潜力。
更新日期：2021-08-19
中文翻译：
芝麻素通过抑制 TRIM44 和 NF-κB 信号传导在食管鳞状细胞癌中发挥抗肿瘤活性
已知含有三方基序的 44 (TRIM44) 在包括食道癌在内的多种人类癌症中发挥致癌作用。芝麻素对各种癌症具有有效的抗炎和抗癌特性。本研究旨在揭示芝麻素和 TRIM44 在食管癌中的生物学功能。通过 RT-qPCR 测定和蛋白质印迹测定食管鳞状细胞癌 (ESCC) 细胞系和组织中的 TRIM44 表达。分别通过小鼠模型和CCK-8测定评估芝麻素和TRIM44对体内和体外ESCC细胞生长的影响。我们发现与对应物相比，TRIM44 在 ESCC 细胞系和组织中显着上调。芝麻素处理或TRIM44的消耗显着降低了ESCC细胞增殖。核因子 kappa B (NF-κB) 和 toll 样受体 4 (TLR4) 信号通路可能参与芝麻素介导的 TRIM44 抑制。最后，我们发现口服芝麻素可显着抑制裸鼠的肿瘤生长或 ESCC。我们的研究结果表明，芝麻素通过抑制 NF-κB 信号通路在 ESCC 中发挥抗肿瘤活性，证明了其治疗食管癌的潜力。
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