Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency Collaborative Innovation Center of Chemical Science and Engineering School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, P. R. China.
Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, 300072, P. R. China.
Singapore Institute of Food and Biotechnology Innovation, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #01-01, Singapore, 138669, Singapore.
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois, 61801, USA.
Sulfoquinovose is a globally abundant organosulfur compound. Degradation by communities of anaerobic bacteria produce 3-hydroxypropanesulfonate, catalysed by sulfopropionaldehyde reductase HpfD. Biochemical investigation of HpfD revealed dehydrogenase activity for a range of alcohols, including 3-hydroxypropanesulfonate, 4-hydroxybutanesulfonate and γ-hydroxybutyrate. Bioinformatics investigations suggest involvement of HpfD homologs in 3-HPS and γ-aminobutyrate degradation.
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