Objective

To verify a behavioral device for the detection of learning, memory, and affective disorders in post-weaning socially isolated rats.

Methods

We tested the behavioral changes in post-weaning socially isolated rats using a multi-function closed maze, a self-developed behavioral device, against the classical mood disorder detection method, the IntelliCage system and Morris water maze.

Results

In the multifunctional closed maze experiment, the spatial learning and memory ability of post-weaning socially isolated rats decreased, which was consistent with the results of the water maze and IntelliCage system. Furthermore, the behavioral changes in the post-weaning socially isolated rats in the multi-function closed maze test were the same as those of the forced swimming and open field tests, indicating that the rats had depression- and anxiety-like behaviors.

Conclusion

A multi-function closed maze can detect emotional changes, spatial learning ability, and memory ability.

中文翻译：

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用于检测断奶后社会孤立大鼠情感障碍和空间认知障碍的多功能封闭迷宫的验证

客观的

验证一种行为装置，用于检测断奶后社会孤立大鼠的学习、记忆和情感障碍。

方法

我们使用多功能封闭迷宫（一种自行开发的行为装置）与经典的情绪障碍检测方法、IntelliCage 系统和 Morris 水迷宫测试断奶后社会孤立大鼠的行为变化。

结果

在多功能封闭迷宫实验中，断奶后社会隔离大鼠的空间学习记忆能力下降，这与水迷宫和IntelliCage系统的结果一致。此外，断奶后社会隔离大鼠在多功能封闭迷宫试验中的行为变化与强迫游泳和旷场试验相同，表明大鼠有抑郁和焦虑样行为。

结论

多功能封闭迷宫可以检测情绪变化、空间学习能力和记忆能力。