Inflammation during critical windows of development contributes to behavioral affect later in life. In this of Neuron, Cao et al. (2021) demonstrate a novel mechanism through which early life Tlr4-dependent inflammation in microglia permanently alters neuronal function and leaves male mice susceptible to stress-induced depressive-like behaviors.

中文翻译：

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小胶质细胞的黄金时间：当压力和感染发生冲突时

发育关键窗口期间的炎症会影响生命后期的行为。在Neuron 中，Cao 等人。(2021) 展示了一种新机制，通过该机制，小胶质细胞中早期依赖 Tlr4 的炎症会永久性地改变神经元功能，并使雄性小鼠容易受到压力诱导的抑郁样行为的影响。