To systematically evaluate the risk factors of lower urinary tract dysfunction in patients with Parkinson's disease(PD), and to provide theoretical basis for clinical medical staff to identify the risk factors of lower urinary tract dysfunction in patients with PD. From the establishment of the database to January 2021, PubMed, the Cochrane Library, EMBASE, Web of Science, other English database, were searched for literatures about the risk factors of lower urinary tract dysfunction in patients with Parkinson's disease. According to the inclusion and exclusion criteria, after browsing the title, abstract and full text, the high-quality literature in line with the inclusion criteria was selected, and the Newcastle-Ottawa Scale（NOS）document quality evaluation tool was used to evaluate the literature quality and extract the data. The included research results were analyzed by RevMan 5.3 software. A total of 8 studies were included for Meta analysis. The results showed that 7 of the 20 related risk factors were statistically significant, and the statistically significant risk factors were duration of disease [Mean Difference (MD)= 0.59, 95% Confidence Interval (CI) (0.04, 1.14), P < 0.005], age [MD = 2.01, 95%CI (−0.36, 3.34), P < 0.005], Hoehn-Yahr (H-Y) score >2 [Odds Ratio (OR) = 1.56, 95%CI (1.09, 2.23), P < 0.001], sleep disorder [OR = 1.79, 95%CI (1.36,2.35), P < 0.001], constipation [OR = 1.88, 95%CI (1.42,2.48), P < 0.001], unified Parkinson’s disease rating scale (UPDRS III) [MD= 4.43, 95%CI (2.20, 6.66), P < 0.001], Mini-mental state examination (MMSE) [MD = −1.16, 95%CI (1.23, −1.09), P < 0.001]. Age, duration of disease, H-Y score >2, sleep disorder, constipation, higher UPDRS Ⅲ score and lower MMSE score were the risk factors of lower urinary tract dysfunction in patients with Parkinson's disease.

系统评价帕金森病(PD)患者下尿路功能障碍的危险因素,为临床医务人员识别PD患者下尿路功能障碍的危险因素提供理论依据。从建库至2021年1月，通过PubMed、Cochrane图书馆、EMBASE、Web of Science等英文数据库，检索帕金森病患者下尿路功能障碍危险因素相关文献。根据纳入排除标准，浏览标题、摘要和全文后，筛选出符合纳入标准的优质文献，采用纽卡斯尔-渥太华量表（NOS）文献质量评价工具对文献进行评价。文献质量和提取数据。纳入的研究结果采用RevMan 5.3软件进行分析。Meta分析共纳入8项研究。结果显示，20个相关危险因素中有7个具有统计学意义，具有统计学意义的危险因素为病程[平均差（MD）= 0.59，95%置信区间（CI）（0.04，1.14），P  < 0.005], 年龄 [MD = 2.01, 95%CI (-0.36, 3.34), P  < 0.005], Hoehn-Yahr (HY) 评分 >2 [优势比 (OR) = 1.56, 95%CI (1.09, 2.23), P  < 0.001], 睡眠障碍 [OR = 1.79, 95%CI (1.36,2.35), P  < 0.001], 便秘 [OR = 1.88, 95%CI (1.42,2.48), P  < 0.001],统一帕金森病评定量表 (UPDRS III) [MD= 4.43, 95%CI (2.20, 6.66), P  < 0.001], 简易精神状态检查 (MMSE) [MD = -1.16, 95%CI (1.23, -1.09) , P  < 0.001]。年龄、病程、HY评分>2、睡眠障碍、便秘、UPDRSⅢ评分较高和MMSE评分较低是帕金森病患者下尿路功能障碍的危险因素。